{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(11)"],"submitter":["Hamed AM"],"pubmed_abstract":["<b>Background/Objectives:</b> Glyphosate-based herbicides (GBHs) are widely used agrochemicals implicated in nephrotoxicity through mechanisms involving oxidative stress, inflammation, and tissue remodeling. Natural peptides such as melittin possess potent anti-inflammatory and antioxidant properties; however, their therapeutic use is limited by instability and toxicity. Nanotechnology-based encapsulation presents a promising approach to overcoming these challenges. Objective: This study aimed to evaluate the protective effects of melittin-loaded chitosan-TPP nanoparticles (MEL-NPs) against glyphosate-induced nephrotoxicity in rats, with emphasis on oxidative, inflammatory, and apoptotic pathways. <b>Methods:</b> Female Wistar rats were divided into four groups: control, glyphosate (5 mg/k"],"journal":["Biomedicines"],"pagination":["2607"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12650702"],"repository":["biostudies-literature"],"pubmed_title":["Melittin Nanoparticles Mitigate Glyphosate-Induced Nephrotoxicity via Cytokine Modulation and Bax/Nrf2 Pathways."],"pmcid":["PMC12650702"],"pubmed_authors":["Mahrous NS","Eldeeb Mohana ZE","Monir DM","Elbahy DA","Soliman SS","Abdellah WA","Abdel-Latif HMR","Hamouda EEM","Fouda NAR","Hamed AM","Ahmed ARH","Abouelella AMA","Mahmoud Abdelfattah Elkassas AM"],"additional_accession":[]},"is_claimable":false,"name":"Melittin Nanoparticles Mitigate Glyphosate-Induced Nephrotoxicity via Cytokine Modulation and Bax/Nrf2 Pathways.","description":"<b>Background/Objectives:</b> Glyphosate-based herbicides (GBHs) are widely used agrochemicals implicated in nephrotoxicity through mechanisms involving oxidative stress, inflammation, and tissue remodeling. Natural peptides such as melittin possess potent anti-inflammatory and antioxidant properties; however, their therapeutic use is limited by instability and toxicity. Nanotechnology-based encapsulation presents a promising approach to overcoming these challenges. Objective: This study aimed to evaluate the protective effects of melittin-loaded chitosan-TPP nanoparticles (MEL-NPs) against glyphosate-induced nephrotoxicity in rats, with emphasis on oxidative, inflammatory, and apoptotic pathways. <b>Methods:</b> Female Wistar rats were divided into four groups: control, glyphosate (5 mg/k","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-20T03:16:25.294Z","creation":"2026-05-20T03:13:10.644Z"},"accession":"S-EPMC12650702","cross_references":{"pubmed":["41301702"],"doi":["10.3390/biomedicines13112607"]}}