{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pauletti GM"],"funding":["Eunice Kennedy Shriver National Institute of Child Health and Human Development","NICHD NIH HHS"],"pagination":["858"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12652176"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(11)"],"pubmed_abstract":["The utility of bioresponsive multifunctional hydrogel compositions for biomedical applications is rapidly increasing due to the diverse array of biological stimuli that can profoundly alter physicochemical gel properties that benefit therapeutic interventions. The purpose of this research is to explore a bioresponsive hydrogel as a drug-free bioengineering concept to fortify the natural physical contraceptive barriers at the cervicovaginal junction. The results of this research demonstrate that a hydrogel comprising 4% (<i>w</i>/<i>w</i>) Carbopol<sup>®</sup> 974P and 4% (<i>w</i>/<i>w</i>) polyvinylpyrrolidone (CP4%/PVP4%) undergoes bioresponsive structural changes in the presence of simulated seminal fluid, pH 7.7, (SFS) that increases the work required to spread the gel under physiologi"],"journal":["Gels (Basel, Switzerland)"],"pubmed_title":["Bioresponsive Hydrogel for On-Demand Nonhormonal Contraception."],"pmcid":["PMC12652176"],"funding_grant_id":["R33HD099748 and X01HD104420","R33 HD099748"],"pubmed_authors":["Yamamoto HS","Santi CM","Pauletti GM","Lewis J","Alobaidi S","Li P","Dwivedi P","Ibrahim A","Borrego-Alvarez A","Fichorova RN"],"additional_accession":[]},"is_claimable":false,"name":"Bioresponsive Hydrogel for On-Demand Nonhormonal Contraception.","description":"The utility of bioresponsive multifunctional hydrogel compositions for biomedical applications is rapidly increasing due to the diverse array of biological stimuli that can profoundly alter physicochemical gel properties that benefit therapeutic interventions. The purpose of this research is to explore a bioresponsive hydrogel as a drug-free bioengineering concept to fortify the natural physical contraceptive barriers at the cervicovaginal junction. The results of this research demonstrate that a hydrogel comprising 4% (<i>w</i>/<i>w</i>) Carbopol<sup>®</sup> 974P and 4% (<i>w</i>/<i>w</i>) polyvinylpyrrolidone (CP4%/PVP4%) undergoes bioresponsive structural changes in the presence of simulated seminal fluid, pH 7.7, (SFS) that increases the work required to spread the gel under physiologi","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-05T03:11:23.135Z","creation":"2026-06-05T03:07:09.301Z"},"accession":"S-EPMC12652176","cross_references":{"pubmed":["41294543"],"doi":["10.3390/gels11110858"]}}