{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lin TK"],"funding":["Ministry of Science and Technology, Taiwan","China Medical University, Taiwan","National Science and Technology Council, Taiwan","Hualien Tzu Chi Hospital"],"pagination":["1707"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12653036"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(11)"],"pubmed_abstract":["Contact dermatitis is a common inflammatory skin disorder characterized by erythematous and pruritic lesions caused by irritant exposure. <i>Ohwia caudata</i>, a traditional medicinal plant, possesses anti-inflammatory and antioxidant properties, but its dermatoprotective potential remains unclear. To investigate the protective effects and mechanisms of <i>Ohwia caudata</i> leaves' hydroethanolic extract in a murine model of TPA-induced contact dermatitis. Major phytochemicals in <i>Ohwia caudata</i> extract were identified by HPLC-MS. SKH1/J hairless mice were topically treated with <i>Ohwia caudata</i> extract following TPA stimulation. Skin barrier function was assessed by transepidermal water loss and hydration. Inflammatory (IL-6, TNF-α, TGF-β), antioxidant (SIRT1, Nrf2, HO-1), and ER"],"journal":["Life (Basel, Switzerland)"],"pubmed_title":["Protective Anti-Inflammatory and Antioxidant Mechanisms of &lt;i&gt;Ohwia caudata&lt;/i&gt; Leaf Hydroethanolic Extract in a Dermatitis Mouse Model."],"pmcid":["PMC12653036"],"funding_grant_id":["no"],"pubmed_authors":["Kuo WW","Tsai BC","Ho TJ","Hsieh DJ","Huang CY","Lin TK","Lin SZ","Tsai CL","Kao SW","Kuo CH"],"additional_accession":[]},"is_claimable":false,"name":"Protective Anti-Inflammatory and Antioxidant Mechanisms of &lt;i&gt;Ohwia caudata&lt;/i&gt; Leaf Hydroethanolic Extract in a Dermatitis Mouse Model.","description":"Contact dermatitis is a common inflammatory skin disorder characterized by erythematous and pruritic lesions caused by irritant exposure. <i>Ohwia caudata</i>, a traditional medicinal plant, possesses anti-inflammatory and antioxidant properties, but its dermatoprotective potential remains unclear. To investigate the protective effects and mechanisms of <i>Ohwia caudata</i> leaves' hydroethanolic extract in a murine model of TPA-induced contact dermatitis. Major phytochemicals in <i>Ohwia caudata</i> extract were identified by HPLC-MS. SKH1/J hairless mice were topically treated with <i>Ohwia caudata</i> extract following TPA stimulation. Skin barrier function was assessed by transepidermal water loss and hydration. Inflammatory (IL-6, TNF-α, TGF-β), antioxidant (SIRT1, Nrf2, HO-1), and ER","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-05-20T03:16:55.776Z","creation":"2026-05-20T03:08:55.061Z"},"accession":"S-EPMC12653036","cross_references":{"pubmed":["41302132"],"doi":["10.3390/life15111707"]}}