{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liang B"],"funding":["Molecular Mechanisms of BdorOr45a in cis-Linalool Oxide Recognition in Female Bactrocera dorsalis"],"pagination":["1139"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12653480"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(11)"],"pubmed_abstract":["<i>Bactrocera dorsalis</i> Hendel is a devastating invasive pest that costs billions of dollars in agricultural losses worldwide. Current control strategies rely heavily on male-specific attractants such as methyl eugenol, which are less effective against females, underscoring the need for female-targeted control approaches. Here, we investigated the molecular mechanisms underlying female attraction to cis-linalool oxide by functionally characterizing the odorant receptor <i>OR45a</i>, identifying it as a molecular target for female-oriented pest management. We conducted spatiotemporal expression analysis of <i>OR45a</i> in response to cis-linalool oxide, followed by RNAi and behavioral assays. Phylogenetic analysis of OR45a orthologs from 10 Dipteran species, combined with structural topo"],"journal":["Insects"],"pubmed_title":["Odorant Receptor &lt;i&gt;OR45a&lt;/i&gt; Mediates Female-Specific Attraction to &lt;i&gt;cis&lt;/i&gt;-Linalool Oxide in &lt;i&gt;Bactrocera dorsalis&lt;/i&gt;."],"pmcid":["PMC12653480"],"funding_grant_id":["RZ2500008301"],"pubmed_authors":["Wen J","Xiao L","Lu X","Wang S","Cao F","Miao W","Liang B"],"additional_accession":[]},"is_claimable":false,"name":"Odorant Receptor &lt;i&gt;OR45a&lt;/i&gt; Mediates Female-Specific Attraction to &lt;i&gt;cis&lt;/i&gt;-Linalool Oxide in &lt;i&gt;Bactrocera dorsalis&lt;/i&gt;.","description":"<i>Bactrocera dorsalis</i> Hendel is a devastating invasive pest that costs billions of dollars in agricultural losses worldwide. Current control strategies rely heavily on male-specific attractants such as methyl eugenol, which are less effective against females, underscoring the need for female-targeted control approaches. Here, we investigated the molecular mechanisms underlying female attraction to cis-linalool oxide by functionally characterizing the odorant receptor <i>OR45a</i>, identifying it as a molecular target for female-oriented pest management. We conducted spatiotemporal expression analysis of <i>OR45a</i> in response to cis-linalool oxide, followed by RNAi and behavioral assays. Phylogenetic analysis of OR45a orthologs from 10 Dipteran species, combined with structural topo","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-05-19T03:22:17.003Z","creation":"2026-05-19T03:11:57.796Z"},"accession":"S-EPMC12653480","cross_references":{"pubmed":["41302885"],"doi":["10.3390/insects16111139"]}}