{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tukanov E"],"funding":["Flemish government agency for Innovation by Science and Technology"],"pagination":["8142"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12653495"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(22)"],"pubmed_abstract":["<b>Background:</b> Mandibular advancement device (MAD) therapy is a non-invasive treatment for obstructive sleep apnea (OSA). Although the effect of MAD on OSA outcomes is widely known, its effect on the upper airway collapse degree remains poorly understood. This study aimed to assess the impact of MAD therapy on site-specific airway collapse degree during drug-induced sleep endoscopy (DISE). <b>Methods:</b> One hundred participants were recruited and underwent a baseline polysomnography. Overall, 69 participants with OSA (AHI 5-50 events/h) underwent DISE at baseline and with MAD set to 75% of maximal mandibular protrusion. Collapse degree (none, partial, complete) was evaluated at the palate, oropharynx, tongue base, hypopharynx, and epiglottis without and with MAD. Ordinal logistic reg"],"journal":["Journal of clinical medicine"],"pubmed_title":["Effect of Mandibular Advancement Device Treatment on the Site-Specific Degree of Upper Airway Collapse During Drug-Induced Sleep Endoscopy."],"pmcid":["PMC12653495"],"funding_grant_id":["IWT-090864"],"pubmed_authors":["Dieltjens M","Verbruggen AE","Tukanov E","Van de Heyning PH","Op de Beeck S","Verbraecken JA","Vanderveken OM","Vroegop AV","Braem MJ"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Mandibular Advancement Device Treatment on the Site-Specific Degree of Upper Airway Collapse During Drug-Induced Sleep Endoscopy.","description":"<b>Background:</b> Mandibular advancement device (MAD) therapy is a non-invasive treatment for obstructive sleep apnea (OSA). Although the effect of MAD on OSA outcomes is widely known, its effect on the upper airway collapse degree remains poorly understood. This study aimed to assess the impact of MAD therapy on site-specific airway collapse degree during drug-induced sleep endoscopy (DISE). <b>Methods:</b> One hundred participants were recruited and underwent a baseline polysomnography. Overall, 69 participants with OSA (AHI 5-50 events/h) underwent DISE at baseline and with MAD set to 75% of maximal mandibular protrusion. Collapse degree (none, partial, complete) was evaluated at the palate, oropharynx, tongue base, hypopharynx, and epiglottis without and with MAD. Ordinal logistic reg","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-05-19T03:15:26.932Z","creation":"2026-05-19T03:11:17.238Z"},"accession":"S-EPMC12653495","cross_references":{"pubmed":["41303178"],"doi":["10.3390/jcm14228142"]}}