{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kang HG"],"funding":["Japan Society for the Promotion of Science"],"pagination":["5198"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12654580"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(22)"],"pubmed_abstract":["Gadolinium (Gd)-based nanomaterials have attracted a considerable amount of attention in cancer treatment research due to their applicability in radiotherapy. However, the clinical translation of Gd-based nanomaterials is limited by their high density and poor dispersibility in aqueous media, thereby necessitating surface functionalization with biocompatible polymers. In this study, gadolinium tungstate (Gd<sub>2</sub>(WO<sub>4</sub>)<sub>3</sub>) nanoflakes (GW Nfs) were functionalized with poly(glycerol) (PG) to enhance their dispersibility and stability in aqueous media. Due to their high-<i>Z</i> elemental composition, the GW Nfs generated reactive oxygen species (ROS) under X-ray irradiation, with improved dispersibility induced by PG functionalization further enhancing ROS productivity compared to GW Nfs. Furthermore, PG-GW loaded with the photosensitizer chlorin e6 (Ce6) demonstrated strong photocytotoxicity at Ce6 concentrations as low as 0.2 μg mL<sup>-1</sup> under light irradiation. Taken together, these results demonstrate that PG-GW/Ce6 is a promising nanomaterial for photodynamic therapy while also offering prospects for bimodal photon cancer therapy with X-rays."],"journal":["Materials (Basel, Switzerland)"],"pubmed_title":["Poly(glycerol)-Functionalized Gadolinium Tungstate Nanoflakes Loaded with Chlorin e6: Photodynamic Efficacy and Radiosensitization Potential for Multimodal Cancer Therapy."],"pmcid":["PMC12654580"],"funding_grant_id":["Young Researchers' Exchange Programme"],"pubmed_authors":["Gerken LRH","Kang HG"],"additional_accession":[]},"is_claimable":false,"name":"Poly(glycerol)-Functionalized Gadolinium Tungstate Nanoflakes Loaded with Chlorin e6: Photodynamic Efficacy and Radiosensitization Potential for Multimodal Cancer Therapy.","description":"Gadolinium (Gd)-based nanomaterials have attracted a considerable amount of attention in cancer treatment research due to their applicability in radiotherapy. However, the clinical translation of Gd-based nanomaterials is limited by their high density and poor dispersibility in aqueous media, thereby necessitating surface functionalization with biocompatible polymers. In this study, gadolinium tungstate (Gd<sub>2</sub>(WO<sub>4</sub>)<sub>3</sub>) nanoflakes (GW Nfs) were functionalized with poly(glycerol) (PG) to enhance their dispersibility and stability in aqueous media. Due to their high-<i>Z</i> elemental composition, the GW Nfs generated reactive oxygen species (ROS) under X-ray irradiation, with improved dispersibility induced by PG functionalization further enhancing ROS productivity compared to GW Nfs. Furthermore, PG-GW loaded with the photosensitizer chlorin e6 (Ce6) demonstrated strong photocytotoxicity at Ce6 concentrations as low as 0.2 μg mL<sup>-1</sup> under light irradiation. Taken together, these results demonstrate that PG-GW/Ce6 is a promising nanomaterial for photodynamic therapy while also offering prospects for bimodal photon cancer therapy with X-rays.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-05-19T03:27:23.712Z","creation":"2026-05-19T03:12:23.098Z"},"accession":"S-EPMC12654580","cross_references":{"pubmed":["41304042"],"doi":["10.3390/ma18225198"]}}