{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma Y"],"funding":["Science & Technology Innovation Program of Yongjiang 2035"],"pagination":["708"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12654858"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(11)"],"pubmed_abstract":["<b>Background/Objectives</b>: Chronic colitis presents a growing global health burden with rising incidence. This study investigated the ameliorative effect of <i>Dendrobium officinale</i> polysaccharide (DOP) against dextran sulfate sodium (DSS)-induced chronic colitis in mice, specifically examining its dual modulation of gut microbiota and metabolic pathways. <b>Methods</b>: DOP was extracted and purified from <i>Dendrobium officinale</i> stems and leaves. A chronic colitis model was established in male C57BL/6J mice via DSS induction. Eighty-four mice were randomized into seven groups: control, model, low/high-dose leaf-DOP, low/high-dose stem-DOP, and sulfasalazine positive control. We assessed body weight, disease activity index (DAI), colon length, splenic/thymic indices, inflammato"],"journal":["Metabolites"],"pubmed_title":["&lt;i&gt;Dendrobium officinale&lt;/i&gt; Polysaccharide Relieves the DSS-Induced Chronic Colitis in C57BL/6J Mice and Regulates Colonic Microflora Structure."],"pmcid":["PMC12654858"],"funding_grant_id":["2024Z281"],"pubmed_authors":["Xing J","Li J","Yang Y","Tao W","Zhang H","Ma Y","Zhou W","Yuan X"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;Dendrobium officinale&lt;/i&gt; Polysaccharide Relieves the DSS-Induced Chronic Colitis in C57BL/6J Mice and Regulates Colonic Microflora Structure.","description":"<b>Background/Objectives</b>: Chronic colitis presents a growing global health burden with rising incidence. This study investigated the ameliorative effect of <i>Dendrobium officinale</i> polysaccharide (DOP) against dextran sulfate sodium (DSS)-induced chronic colitis in mice, specifically examining its dual modulation of gut microbiota and metabolic pathways. <b>Methods</b>: DOP was extracted and purified from <i>Dendrobium officinale</i> stems and leaves. A chronic colitis model was established in male C57BL/6J mice via DSS induction. Eighty-four mice were randomized into seven groups: control, model, low/high-dose leaf-DOP, low/high-dose stem-DOP, and sulfasalazine positive control. We assessed body weight, disease activity index (DAI), colon length, splenic/thymic indices, inflammato","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-20T03:20:46.726Z","creation":"2026-05-20T03:13:55.244Z"},"accession":"S-EPMC12654858","cross_references":{"pubmed":["41295294"],"doi":["10.3390/metabo15110708"]}}