biostudies-literatureUnknown20(11)Hua Z<h4>Background</h4>Thyroid hormone sensitivity has emerged as a critical factor in various diseases. However, its relationship with ischemic stroke-associated pneumonia (iSAP) in euthyroid patients with ischemic stroke remains poorly understood. This study aims to elucidate the association between thyroid hormone sensitivity indices and iSAP risk.<h4>Methods</h4>A total of 1,767 euthyroid patients with ischemic stroke were enrolled and categorized into the iSAP group (n = 376) and the non-iSAP group (n = 1,391). Univariate and multivariate logistic regression analyses were performed to assess the association between thyroid hormone sensitivity indices-including free triiodothyronine (FT3), free thyroxine (FT4), FT3/FT4 ratio, thyroid-stimulating hormone index (TSHI), Thyrotroph T4 ResistanPloS onee0333057https://www.ebi.ac.uk/biostudies/studies/S-EPMC12654940biostudies-literatureAssociation between thyroid hormone sensitivity and ischemic stroke-associated pneumonia: The role of FT3/FT4 ratio.PMC12654940Hua ZZhang YRao ZZhu CfalseAssociation between thyroid hormone sensitivity and ischemic stroke-associated pneumonia: The role of FT3/FT4 ratio.<h4>Background</h4>Thyroid hormone sensitivity has emerged as a critical factor in various diseases. However, its relationship with ischemic stroke-associated pneumonia (iSAP) in euthyroid patients with ischemic stroke remains poorly understood. This study aims to elucidate the association between thyroid hormone sensitivity indices and iSAP risk.<h4>Methods</h4>A total of 1,767 euthyroid patients with ischemic stroke were enrolled and categorized into the iSAP group (n = 376) and the non-iSAP group (n = 1,391). Univariate and multivariate logistic regression analyses were performed to assess the association between thyroid hormone sensitivity indices-including free triiodothyronine (FT3), free thyroxine (FT4), FT3/FT4 ratio, thyroid-stimulating hormone index (TSHI), Thyrotroph T4 Resistan2025-01-01T00:00:00Z20252026-06-05T17:57:12.192Z2026-05-19T03:11:58.124ZS-EPMC126549404129667810.1371/journal.pone.0333057