{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qin J"],"funding":["the Natural Science Foundation of Shandong Province"],"pagination":["4462"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12655464"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(22)"],"pubmed_abstract":["Herein, we disclose a novel and efficient cobalt-catalyzed cross-coupling strategy for picolinamide-directed direct C(sp<sup>3</sup>)-H bond formation with <i>N</i>-(phenylsulfanyl)succinimides. This method enables the direct construction of C(sp<sup>3</sup>)-S bonds under mild conditions and exhibits excellent functional group tolerance along with a broad substrate scope. Notably, the catalytic system achieves oxidative C-H functionalization without relying on costly or environmentally detrimental oxidants, offering a more sustainable and practical alternative for C-S bond formation."],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Co(II)-Catalyzed Picolinamide-Directed C(sp&lt;sup&gt;3&lt;/sup&gt;)-S Bond Formation with &lt;i&gt;N&lt;/i&gt;-(phenylsulfanyl)succinimides."],"pmcid":["PMC12655464"],"funding_grant_id":["ZR2022QB125"],"pubmed_authors":["Luo J","Qin J","Zhou S","Wang G","Wang K"],"additional_accession":[]},"is_claimable":false,"name":"Co(II)-Catalyzed Picolinamide-Directed C(sp&lt;sup&gt;3&lt;/sup&gt;)-S Bond Formation with &lt;i&gt;N&lt;/i&gt;-(phenylsulfanyl)succinimides.","description":"Herein, we disclose a novel and efficient cobalt-catalyzed cross-coupling strategy for picolinamide-directed direct C(sp<sup>3</sup>)-H bond formation with <i>N</i>-(phenylsulfanyl)succinimides. This method enables the direct construction of C(sp<sup>3</sup>)-S bonds under mild conditions and exhibits excellent functional group tolerance along with a broad substrate scope. Notably, the catalytic system achieves oxidative C-H functionalization without relying on costly or environmentally detrimental oxidants, offering a more sustainable and practical alternative for C-S bond formation.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-05-19T03:15:21.976Z","creation":"2026-05-19T03:10:56.369Z"},"accession":"S-EPMC12655464","cross_references":{"pubmed":["41302517"],"doi":["10.3390/molecules30224462"]}}