biostudies-literatureQin Jthe Natural Science Foundation of Shandong Province4462https://www.ebi.ac.uk/biostudies/studies/S-EPMC12655464biostudies-literatureUnknown30(22)Herein, we disclose a novel and efficient cobalt-catalyzed cross-coupling strategy for picolinamide-directed direct C(sp³)-H bond formation with <i>N</i>-(phenylsulfanyl)succinimides. This method enables the direct construction of C(sp³)-S bonds under mild conditions and exhibits excellent functional group tolerance along with a broad substrate scope. Notably, the catalytic system achieves oxidative C-H functionalization without relying on costly or environmentally detrimental oxidants, offering a more sustainable and practical alternative for C-S bond formation.Molecules (Basel, Switzerland)Co(II)-Catalyzed Picolinamide-Directed C(sp&lt;sup&gt;3&lt;/sup&gt;)-S Bond Formation with &lt;i&gt;N&lt;/i&gt;-(phenylsulfanyl)succinimides.PMC12655464ZR2022QB125Luo JQin JZhou SWang GWang KfalseCo(II)-Catalyzed Picolinamide-Directed C(sp&lt;sup&gt;3&lt;/sup&gt;)-S Bond Formation with &lt;i&gt;N&lt;/i&gt;-(phenylsulfanyl)succinimides.Herein, we disclose a novel and efficient cobalt-catalyzed cross-coupling strategy for picolinamide-directed direct C(sp³)-H bond formation with <i>N</i>-(phenylsulfanyl)succinimides. This method enables the direct construction of C(sp³)-S bonds under mild conditions and exhibits excellent functional group tolerance along with a broad substrate scope. Notably, the catalytic system achieves oxidative C-H functionalization without relying on costly or environmentally detrimental oxidants, offering a more sustainable and practical alternative for C-S bond formation.2025-01-01T00:00:00Z2025 Nov2026-05-19T03:15:21.976Z2026-05-19T03:10:56.369ZS-EPMC126554644130251710.3390/molecules30224462