biostudies-literatureUnknown13(11)Felek DThis study investigates the potential role of microplastics in the development of diabetes mellitus and assesses their presence in individuals undergoing insulin therapy. A total of 100 participants were included: 50 insulin-dependent diabetic patients and 50 healthy controls. The diabetic group was divided into two subgroups based on their insulin regimen: those receiving one daily injection of basal insulin and those receiving four injections of basal and short-acting insulin. Blood samples were analysed for microplastic content using chromatographic methods (LC/GC-MSMS and LCTOF MS). The findings revealed that diabetic patients had significantly higher serum microplastic levels (3.14 ± 1.30 µg/mL) than healthy individuals (1.50 ± 0.89 µg/mL, <i>p</i> < 0.05). Within the diabetic group, Toxics926https://www.ebi.ac.uk/biostudies/studies/S-EPMC12656115biostudies-literatureAssessment of Microplastic Exposure in Diabetic Patients Using Insulin.PMC12656115Erkoc MFYaylacı MFelek DTurksoy VAfalseAssessment of Microplastic Exposure in Diabetic Patients Using Insulin.This study investigates the potential role of microplastics in the development of diabetes mellitus and assesses their presence in individuals undergoing insulin therapy. A total of 100 participants were included: 50 insulin-dependent diabetic patients and 50 healthy controls. The diabetic group was divided into two subgroups based on their insulin regimen: those receiving one daily injection of basal insulin and those receiving four injections of basal and short-acting insulin. Blood samples were analysed for microplastic content using chromatographic methods (LC/GC-MSMS and LCTOF MS). The findings revealed that diabetic patients had significantly higher serum microplastic levels (3.14 ± 1.30 µg/mL) than healthy individuals (1.50 ± 0.89 µg/mL, <i>p</i> < 0.05). Within the diabetic group, 2025-01-01T00:00:00Z2025 Oct2026-05-20T03:18:38.146Z2026-05-20T03:09:01.695ZS-EPMC126561154130447810.3390/toxics13110926