{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["32"],"submitter":["Carreno M"],"pubmed_abstract":["Congenital toxoplasmosis is a fetal infection resulting from the transplacental transmission of Toxoplasma gondii in mothers who seroconvert during pregnancy. Neonatal diagnosis has recently been improved through the identification by L'Ollivier et al. (2012) and Peyclit et al. (2023) of a pathognomonic marker for congenital toxoplasmosis: the IgM triplet, corresponding to three high molecular weight bands of 75, 90, and 100 kDa, respectively found on the mother-child immunoblot pair profile. This is a new concept, as these three IgM bands reflect an immune response targeting proteins involved in vertical transmission of T. gondii. These proteins may be T. gondii secreted or non-secreted effectors implicated in host cell invasion, immune modulation, and parasite virulence. In this study, i"],"journal":["Parasite (Paris, France)"],"pagination":["72"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12656376"],"repository":["biostudies-literature"],"pubmed_title":["Protein characterization of the IgM triplet involved in the diagnosis of congenital toxoplasmosis."],"pmcid":["PMC12656376"],"pubmed_authors":["Diemer H","L'Ollivier C","Carreno M","Villena I","Peyclit L","Schaeffer-Reiss C","Villard O"],"additional_accession":[]},"is_claimable":false,"name":"Protein characterization of the IgM triplet involved in the diagnosis of congenital toxoplasmosis.","description":"Congenital toxoplasmosis is a fetal infection resulting from the transplacental transmission of Toxoplasma gondii in mothers who seroconvert during pregnancy. Neonatal diagnosis has recently been improved through the identification by L'Ollivier et al. (2012) and Peyclit et al. (2023) of a pathognomonic marker for congenital toxoplasmosis: the IgM triplet, corresponding to three high molecular weight bands of 75, 90, and 100 kDa, respectively found on the mother-child immunoblot pair profile. This is a new concept, as these three IgM bands reflect an immune response targeting proteins involved in vertical transmission of T. gondii. These proteins may be T. gondii secreted or non-secreted effectors implicated in host cell invasion, immune modulation, and parasite virulence. In this study, i","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-07-15T13:20:39.035Z","creation":"2026-07-05T03:08:07.401Z"},"accession":"S-EPMC12656376","cross_references":{"pubmed":["41296914"],"doi":["10.1051/parasite/2025065"]}}