{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tang P"],"funding":["Natural Science Foundation of Jiangxi Province of China","National Natural Science Foundation of China"],"pagination":["1087"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12656734"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(11)"],"pubmed_abstract":["While previous studies have extensively demonstrated that summer heat stress (HS) impairs oocyte quality via follicular granulosa cell (GC) mediation, the molecular mechanisms underlying HS-induced GC-mediated oocyte damage-particularly at the multi-omics level-remain poorly understood. This study integrated metabolomic and transcriptomic analyses of GCs from gilts under seasonal thermal stress (winter CON vs. summer HS) to elucidate GC-mediated regulatory networks affecting oocyte quality. Non-targeted metabolomics identified 45 differentially accumulated metabolites (DAMs, <i>p</i> < 0.05), with 69% being lipids/lipid-like molecules enriched in pathways such as glycerophospholipid metabolism, choline metabolism, linoleic acid metabolism, the adipocytokine signaling pathway, and the sphin"],"journal":["Veterinary sciences"],"pubmed_title":["Integrated Metabolomic and Transcriptomic Analysis Decodes Heat Stress-Induced Metabolic Shifts in Gilt Granulosa Cells."],"pmcid":["PMC12656734"],"funding_grant_id":["32202765","20224BAB215055"],"pubmed_authors":["Liu X","Xie X","Huang J","Yin C","Tang P","Si X","Shi Y"],"additional_accession":[]},"is_claimable":false,"name":"Integrated Metabolomic and Transcriptomic Analysis Decodes Heat Stress-Induced Metabolic Shifts in Gilt Granulosa Cells.","description":"While previous studies have extensively demonstrated that summer heat stress (HS) impairs oocyte quality via follicular granulosa cell (GC) mediation, the molecular mechanisms underlying HS-induced GC-mediated oocyte damage-particularly at the multi-omics level-remain poorly understood. This study integrated metabolomic and transcriptomic analyses of GCs from gilts under seasonal thermal stress (winter CON vs. summer HS) to elucidate GC-mediated regulatory networks affecting oocyte quality. Non-targeted metabolomics identified 45 differentially accumulated metabolites (DAMs, <i>p</i> < 0.05), with 69% being lipids/lipid-like molecules enriched in pathways such as glycerophospholipid metabolism, choline metabolism, linoleic acid metabolism, the adipocytokine signaling pathway, and the sphin","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-05-19T03:17:03.991Z","creation":"2026-05-19T03:11:32.952Z"},"accession":"S-EPMC12656734","cross_references":{"pubmed":["41295725"],"doi":["10.3390/vetsci12111087"]}}