{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(11)"],"submitter":["de Villiers de la Noue H"],"pubmed_abstract":["<i>Acinetobacter baumannii</i> is a critical public health threat, particularly with the rise in multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains that limit treatment options. Phage therapy, which uses bacteriophages to target bacteria, offers a promising alternative. We isolated an XDR strain (Ab125) from a burn wound infection and screened 34 phages, identifying vB_AbaM_3098 as the only effective candidate. However, resistance rapidly emerged, producing a derivative strain (Ab139). Interestingly, Ab139, though resistant to vB_AbaM_3098, became susceptible to six previously inactive phages. While various potential determinants were identified through comparative genomics and proteomics, the mechanism causing phage resistance to vB_AbaM_3098 and simultaneous susceptib"],"journal":["Viruses"],"pagination":["1441"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12656882"],"repository":["biostudies-literature"],"pubmed_title":["Rational Design of a Potent Two-Phage Cocktail Against a Contemporary &lt;i&gt;Acinetobacter baumannii&lt;/i&gt; Strain Recovered from a Burned Patient at the Lausanne University Hospital."],"pmcid":["PMC12656882"],"pubmed_authors":["de Villiers de la Noue H","Vuattoux X","Resch G","Golliard G"],"additional_accession":[]},"is_claimable":false,"name":"Rational Design of a Potent Two-Phage Cocktail Against a Contemporary &lt;i&gt;Acinetobacter baumannii&lt;/i&gt; Strain Recovered from a Burned Patient at the Lausanne University Hospital.","description":"<i>Acinetobacter baumannii</i> is a critical public health threat, particularly with the rise in multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains that limit treatment options. Phage therapy, which uses bacteriophages to target bacteria, offers a promising alternative. We isolated an XDR strain (Ab125) from a burn wound infection and screened 34 phages, identifying vB_AbaM_3098 as the only effective candidate. However, resistance rapidly emerged, producing a derivative strain (Ab139). Interestingly, Ab139, though resistant to vB_AbaM_3098, became susceptible to six previously inactive phages. While various potential determinants were identified through comparative genomics and proteomics, the mechanism causing phage resistance to vB_AbaM_3098 and simultaneous susceptib","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-07-05T03:16:37.366Z","creation":"2026-07-05T03:08:18.152Z"},"accession":"S-EPMC12656882","cross_references":{"pubmed":["41305464"],"doi":["10.3390/v17111441"]}}