biostudies-literatureUnknownLebwohl M<h4>Background</h4>Generalized pustular psoriasis (GPP) is a rare, serious, chronic, neutrophilic skin disease, distinct from plaque psoriasis, characterized by recurrent flares of cutaneous erythema and widespread sterile pustules. Patient-centric data on the quality of life (QoL) impacts of GPP remain limited.<h4>Objective</h4>To evaluate the physical and emotional QoL impacts of GPP.<h4>Methods</h4>We used a web-based survey and 90-minute telephone interviews with open-ended questions to evaluate the experiences of adults with GPP across China, Japan, the UK, and the USA. Quantitative measures included the Dermatology Life Quality Index (DLQI), Psoriasis Symptom Scale (PSS), and Worst GPP Pain Numeric Rating Scale (NRS).<h4>Results</h4>21 participants completed the survey; 9 completed tJournal of psoriasis and psoriatic arthritis24755303251401112https://www.ebi.ac.uk/biostudies/studies/S-EPMC12657205biostudies-literaturePatient Experiences on the Diagnosis, Management, and Burden of Generalized Pustular Psoriasis: An International Web Survey and Qualitative Interview Study.PMC12657205Pink AELai ICTrigos DCorrell JRHernandez Daly ACZheng MFujita HLebwohl MTerui TEyerich KSkalicky AMfalsePatient Experiences on the Diagnosis, Management, and Burden of Generalized Pustular Psoriasis: An International Web Survey and Qualitative Interview Study.<h4>Background</h4>Generalized pustular psoriasis (GPP) is a rare, serious, chronic, neutrophilic skin disease, distinct from plaque psoriasis, characterized by recurrent flares of cutaneous erythema and widespread sterile pustules. Patient-centric data on the quality of life (QoL) impacts of GPP remain limited.<h4>Objective</h4>To evaluate the physical and emotional QoL impacts of GPP.<h4>Methods</h4>We used a web-based survey and 90-minute telephone interviews with open-ended questions to evaluate the experiences of adults with GPP across China, Japan, the UK, and the USA. Quantitative measures included the Dermatology Life Quality Index (DLQI), Psoriasis Symptom Scale (PSS), and Worst GPP Pain Numeric Rating Scale (NRS).<h4>Results</h4>21 participants completed the survey; 9 completed t2025-01-01T00:00:00Z2025 Nov2026-06-05T17:56:29.26Z2026-05-19T03:12:04.611ZS-EPMC126572054132324910.1177/24755303251401112