{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xia Q"],"funding":["Natural Science Foundation of Shandong Province","China Postdoctoral Science Foundation","The Young Scientists Fund of the National Natural Science Foundation of China"],"pagination":["2"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12657559"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["51(1)"],"pubmed_abstract":["Neuronal cell damage resulting from ischemic and hypoxic injury is a major pathological event in stroke, with ferroptosis increasingly recognized as a contributing mechanism. In this study, we observed that oxygen-glucose deprivation (OGD) triggered ferroptosis in neuronal cells. By screening of naphthoquinone compounds intervening oxidative stress, we have identified phylloquinone (VK1, also known as vitamin K1) as a potent inhibitor of ferroptosis with significant neuroprotective effects. Phylloquinone also alleviated OGD-induced cellular senescence. Mechanistic investigation revealed that Kruppel-like factor 2 (Klf2) is a potential target of phylloquinone and participates in its neuroprotective effects. These findings indicate that phylloquinone protects neurons from OGD-induced injury "],"journal":["Neurochemical research"],"pubmed_title":["Phylloquinone Attenuates Oxygen-Glucose Deprivation-induced Neuronal Injury by Inhibiting Ferroptosis via the xCT/GPX4 Pathway."],"pmcid":["PMC12657559"],"funding_grant_id":["2024M751849","ZR202211220007","NO. 82403338"],"pubmed_authors":["Li Y","Liu Z","He D","Xia Q","Li L","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Phylloquinone Attenuates Oxygen-Glucose Deprivation-induced Neuronal Injury by Inhibiting Ferroptosis via the xCT/GPX4 Pathway.","description":"Neuronal cell damage resulting from ischemic and hypoxic injury is a major pathological event in stroke, with ferroptosis increasingly recognized as a contributing mechanism. In this study, we observed that oxygen-glucose deprivation (OGD) triggered ferroptosis in neuronal cells. By screening of naphthoquinone compounds intervening oxidative stress, we have identified phylloquinone (VK1, also known as vitamin K1) as a potent inhibitor of ferroptosis with significant neuroprotective effects. Phylloquinone also alleviated OGD-induced cellular senescence. Mechanistic investigation revealed that Kruppel-like factor 2 (Klf2) is a potential target of phylloquinone and participates in its neuroprotective effects. These findings indicate that phylloquinone protects neurons from OGD-induced injury ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T21:33:24.131Z","creation":"2026-05-22T03:11:42.682Z"},"accession":"S-EPMC12657559","cross_references":{"pubmed":["41296108"],"doi":["10.1007/s11064-025-04616-3"]}}