biostudies-literatureUnknown18(11)Arasi S<h4>Background</h4>Data on severity of food allergy across nations are lacking. Building on the World Allergy Organization (WAO) DEFASE (Definition of Food Allergy Severity) score, we aim to explore its global applicability as a grading system for IgE-mediated food allergy (FA) severity.<h4>Methods</h4>An international survey (WAO FASE Project) was conducted using an online questionnaire distributed to WAO members. The survey collected detailed data on diagnostic practices, therapeutic options, characteristics of FA patients, severity of reactions (including anaphylaxis), and eliciting doses of allergenic foods. In addition, FA management costs were examined (medical expenses, medication costs, and impact on quality of life and productivity).<h4>Results</h4>We obtained information from 157The World Allergy Organization journal101123https://www.ebi.ac.uk/biostudies/studies/S-EPMC12657590biostudies-literatureFood allergy severity across the world: A World Allergy Organization international survey.PMC12657590Ortega-Martell JAWinders TRouadi PWGreenhawt MAnsotegui IJEigenmann PWing-Kin Wong GTurner PJGerdts JRapillo RHossny EChinthrajah RSWang LLMuraro AMonge Ortega OPVenter CGupta RSSindher SBSantos ASzajewska HSublett JLArasi SMartin BLMunblit DPodesta MDeschildre AMorais-Almeida MShaker MSBernstein JAKauppi PBrough HAGuzman Melendez MACustovic ATanno LKEbisawa MVickery BJones CGomez RMPatella VFiocchi AChikhladze MSaid MCardona VPeden DBChang YSDahdah LNurmatov UPapadopoulos NGStoddart ANowak-Wegrzyn ACianferoni ACaraballo LBegin PBoyle RJDunnGalvin AMazzuca CLevin MDel Guidice MMWarren CBozzola MFleischer DLozano MAVazquez-Ortiz MRoberts GGiavina-Bianchi PfalseFood allergy severity across the world: A World Allergy Organization international survey.<h4>Background</h4>Data on severity of food allergy across nations are lacking. Building on the World Allergy Organization (WAO) DEFASE (Definition of Food Allergy Severity) score, we aim to explore its global applicability as a grading system for IgE-mediated food allergy (FA) severity.<h4>Methods</h4>An international survey (WAO FASE Project) was conducted using an online questionnaire distributed to WAO members. The survey collected detailed data on diagnostic practices, therapeutic options, characteristics of FA patients, severity of reactions (including anaphylaxis), and eliciting doses of allergenic foods. In addition, FA management costs were examined (medical expenses, medication costs, and impact on quality of life and productivity).<h4>Results</h4>We obtained information from 1572025-01-01T00:00:00Z2025 Nov2026-06-05T21:25:27.065Z2026-05-22T03:08:59.752ZS-EPMC126575904132312710.1016/j.waojou.2025.101123