{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bremard L"],"funding":["EU ERANET Neuron Program"],"pagination":["219"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12657931"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["α-melanocyte-stimulating hormone (α-MSH) is an anorexigenic peptide. In this exploratory study, a targeted proteomic approach was used to detect α-MSH-like bacterial proteins in the gut microbiota of patients with anorexia nervosa (AN) and healthy controls. Enterobacteriaceae chaperone DnaK was identified as an α-MSH-like protein common to both study groups, while caseinolytic protease B (ClpB) was present in patients with AN. These data further link anorexigenic ClpB to the AN pathophysiology."],"journal":["NPJ biofilms and microbiomes"],"pubmed_title":["Targeted proteomics reveal α-MSH-like Enterobacterial ClpB protein in gut microbiota of patients with anorexia nervosa."],"pmcid":["PMC12657931"],"funding_grant_id":["01EW1906A-01EW1906B"],"pubmed_authors":["Lahaye E","Herpertz-Dahlmann B","Ben Mlouka MA","Wallart L","Bremard L","Seitz J","Fetissov SO"],"additional_accession":[]},"is_claimable":false,"name":"Targeted proteomics reveal α-MSH-like Enterobacterial ClpB protein in gut microbiota of patients with anorexia nervosa.","description":"α-melanocyte-stimulating hormone (α-MSH) is an anorexigenic peptide. In this exploratory study, a targeted proteomic approach was used to detect α-MSH-like bacterial proteins in the gut microbiota of patients with anorexia nervosa (AN) and healthy controls. Enterobacteriaceae chaperone DnaK was identified as an α-MSH-like protein common to both study groups, while caseinolytic protease B (ClpB) was present in patients with AN. These data further link anorexigenic ClpB to the AN pathophysiology.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T21:35:36.077Z","creation":"2026-05-22T03:12:35.458Z"},"accession":"S-EPMC12657931","cross_references":{"pubmed":["41298523"],"doi":["10.1038/s41522-025-00850-3"]}}