biostudies-literatureBremard LEU ERANET Neuron Program219https://www.ebi.ac.uk/biostudies/studies/S-EPMC12657931biostudies-literatureUnknown11(1)α-melanocyte-stimulating hormone (α-MSH) is an anorexigenic peptide. In this exploratory study, a targeted proteomic approach was used to detect α-MSH-like bacterial proteins in the gut microbiota of patients with anorexia nervosa (AN) and healthy controls. Enterobacteriaceae chaperone DnaK was identified as an α-MSH-like protein common to both study groups, while caseinolytic protease B (ClpB) was present in patients with AN. These data further link anorexigenic ClpB to the AN pathophysiology.NPJ biofilms and microbiomesTargeted proteomics reveal α-MSH-like Enterobacterial ClpB protein in gut microbiota of patients with anorexia nervosa.PMC1265793101EW1906A-01EW1906BLahaye EHerpertz-Dahlmann BBen Mlouka MAWallart LBremard LSeitz JFetissov SOfalseTargeted proteomics reveal α-MSH-like Enterobacterial ClpB protein in gut microbiota of patients with anorexia nervosa.α-melanocyte-stimulating hormone (α-MSH) is an anorexigenic peptide. In this exploratory study, a targeted proteomic approach was used to detect α-MSH-like bacterial proteins in the gut microbiota of patients with anorexia nervosa (AN) and healthy controls. Enterobacteriaceae chaperone DnaK was identified as an α-MSH-like protein common to both study groups, while caseinolytic protease B (ClpB) was present in patients with AN. These data further link anorexigenic ClpB to the AN pathophysiology.2025-01-01T00:00:00Z2025 Nov2026-06-05T21:35:36.077Z2026-05-22T03:12:35.458ZS-EPMC126579314129852310.1038/s41522-025-00850-3