{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu YJ"],"funding":["Natural Science Foundation of Henan Province (Henan Province Natural Science Foundation)","China Postdoctoral Science Foundation","National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["10586"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12657935"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Precisely constructing homochiral helical nanostructures from achiral molecules by non-covalent interactions remains challenging owing to the untraceable handedness control at different hierarchical levels. Here, we present an aurophilicity-assisted orthogonal assembly strategy, enabling not only the homochiral assembly of an achiral carbene-anchored trinuclear gold cluster with chiral amines but also the inversion of circularly polarized luminescence (CPL). This gold cluster could spontaneously form random right- or left-handed helices, while introduction of chiral amines effectively drives the formation of hierarchically homochiral twists with |g<sub>lum</sub>| of 10<sup>-2</sup>, directed by inherent aurophilicity of gold cluster and orthogonal intermolecular C-H⋅⋅⋅O/N interactions. Fur"],"journal":["Nature communications"],"pubmed_title":["Solvent-mediated chirality inversion in orthogonal hierarchical assembly of achiral carbene-anchored gold cluster."],"pmcid":["PMC12657935"],"funding_grant_id":["252300421174","22105177","92461304","92356304","2021TQ0294"],"pubmed_authors":["Liu Y","Qi XW","Liu YJ","Yu WQ","Zang SQ"],"additional_accession":[]},"is_claimable":false,"name":"Solvent-mediated chirality inversion in orthogonal hierarchical assembly of achiral carbene-anchored gold cluster.","description":"Precisely constructing homochiral helical nanostructures from achiral molecules by non-covalent interactions remains challenging owing to the untraceable handedness control at different hierarchical levels. Here, we present an aurophilicity-assisted orthogonal assembly strategy, enabling not only the homochiral assembly of an achiral carbene-anchored trinuclear gold cluster with chiral amines but also the inversion of circularly polarized luminescence (CPL). This gold cluster could spontaneously form random right- or left-handed helices, while introduction of chiral amines effectively drives the formation of hierarchically homochiral twists with |g<sub>lum</sub>| of 10<sup>-2</sup>, directed by inherent aurophilicity of gold cluster and orthogonal intermolecular C-H⋅⋅⋅O/N interactions. Fur","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T21:22:23.358Z","creation":"2026-05-22T03:09:02.356Z"},"accession":"S-EPMC12657935","cross_references":{"pubmed":["41298441"],"doi":["10.1038/s41467-025-65637-8"]}}