{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Z"],"funding":["Science and Technology Planning Project of Guangzhou","Industry-University-Research Cooperation Project of Jiangsu Province","Pearl River Talent Program of Guangdong Province","National Natural Science Foundation of China","Scientific research foundation for high-level personnel in Jinling Institute of Technology","Guangdong Basic and Applied Basic Research Fund","Natural Science Foundation of Jiangsu Province"],"pagination":["42163"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12658014"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Manganese oxide (MnO<sub>x</sub>)-based nanozymes have attracted growing interest due to their low cost, high catalytic robustness, and adjustable oxidation states that influence enzyme-mimicking performance. In this study, we report a systematic approach to synthesize MnO<sub>x</sub> nanocomposites with tunable Mn valence states via a two-step pyrolysis of Mn-BTC precursors, enabling us to explore their valence-dependent peroxidase-like activities. Among the synthesized forms, Mn<sub>3</sub>O<sub>4</sub> exhibited the highest catalytic efficiency by facilitating the decomposition of H₂O₂ to generate hydroxyl radicals (•OH), which oxidize tetramethylbenzidine (TMB) to produce a blue-colored product. The catalytic mechanism was supported by UV-vis spectroscopy and fluorescence assays. Kinet"],"journal":["Scientific reports"],"pubmed_title":["Manganese oxide (MnO&lt;sub&gt;x&lt;/sub&gt;) as peroxidase-mimicking nanozymes with valence-dependent activity for single-use colorimetric bioassays."],"pmcid":["PMC12658014"],"funding_grant_id":["22375092","2023A1515012820","BK20241846","2024A04J6316","2021QN02X046","BY2021300","jit-b-201811"],"pubmed_authors":["Liu X","Zhang T","Shan H","Zheng H","Zhang Z","An J","Hui Z","Sun G","Dai H","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Manganese oxide (MnO&lt;sub&gt;x&lt;/sub&gt;) as peroxidase-mimicking nanozymes with valence-dependent activity for single-use colorimetric bioassays.","description":"Manganese oxide (MnO<sub>x</sub>)-based nanozymes have attracted growing interest due to their low cost, high catalytic robustness, and adjustable oxidation states that influence enzyme-mimicking performance. In this study, we report a systematic approach to synthesize MnO<sub>x</sub> nanocomposites with tunable Mn valence states via a two-step pyrolysis of Mn-BTC precursors, enabling us to explore their valence-dependent peroxidase-like activities. Among the synthesized forms, Mn<sub>3</sub>O<sub>4</sub> exhibited the highest catalytic efficiency by facilitating the decomposition of H₂O₂ to generate hydroxyl radicals (•OH), which oxidize tetramethylbenzidine (TMB) to produce a blue-colored product. The catalytic mechanism was supported by UV-vis spectroscopy and fluorescence assays. Kinet","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-07T04:36:43.983Z","creation":"2026-06-07T03:07:16.686Z"},"accession":"S-EPMC12658014","cross_references":{"pubmed":["41298572"],"doi":["10.1038/s41598-025-26164-0"]}}