{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(1)"],"submitter":["Li B"],"pubmed_abstract":["Seed weight is a key component of crop yield. However, molecular mechanisms underlying soybean seed weight variation remain largely elusive. Here, we identify a major seed weight determining gene Glycine max SMALL SEED 6 (GmSMS6) that encodes a 14-3-3 protein. GmSMS6 physically and genetically interacts with the transcription factor GmbZIP151 and the RING-type E3 ligase GmUBQ1. GmSMS6 acts as a regulatory hub switch that coordinates the transcriptional activation activity and GmUBQ1-mediated stability of GmbZIP151, primarily repressing cellular expansion of soybean cotyledons. Knocking out GmSMS6 increases seed weight and protein content but decreases oil accumulation in multiple soybean genetic backgrounds. A loss-of-function allele of GmSMS6 is absent in available soybean resources, whil"],"journal":["Nature communications"],"pagination":["10547"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12658019"],"repository":["biostudies-literature"],"pubmed_title":["A 14-3-3 modulator of seed weight and quality for unlocking the yield potential of soybean."],"pmcid":["PMC12658019"],"pubmed_authors":["He C","Gu Y","Chen M","An Z","Li B","Zhu W","Wang Y","Yang C","Yong B","Yu H"],"additional_accession":[]},"is_claimable":false,"name":"A 14-3-3 modulator of seed weight and quality for unlocking the yield potential of soybean.","description":"Seed weight is a key component of crop yield. However, molecular mechanisms underlying soybean seed weight variation remain largely elusive. Here, we identify a major seed weight determining gene Glycine max SMALL SEED 6 (GmSMS6) that encodes a 14-3-3 protein. GmSMS6 physically and genetically interacts with the transcription factor GmbZIP151 and the RING-type E3 ligase GmUBQ1. GmSMS6 acts as a regulatory hub switch that coordinates the transcriptional activation activity and GmUBQ1-mediated stability of GmbZIP151, primarily repressing cellular expansion of soybean cotyledons. Knocking out GmSMS6 increases seed weight and protein content but decreases oil accumulation in multiple soybean genetic backgrounds. A loss-of-function allele of GmSMS6 is absent in available soybean resources, whil","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T21:41:15.071Z","creation":"2026-05-22T03:15:12.536Z"},"accession":"S-EPMC12658019","cross_references":{"pubmed":["41298463"],"doi":["10.1038/s41467-025-65598-y"]}}