biostudies-literatureUnknown8(11)Taylor M<h4>Importance</h4>The prevalence of depression is higher in cancer survivors than in the general population. As the long-term cancer survivor population increases, it is increasingly important to understand risk factors for late-onset depression.<h4>Objective</h4>To identify risk factors associated with late-onset depression in long-term (5-year) survivors of breast, prostate, or colorectal cancer.<h4>Design, setting, and participants</h4>This retrospective cohort study used 2022 linkage of Surveillance, Epidemiology, and End Results (SEER) and Medicare data to identify 5-year survivors of breast, prostate, or colorectal cancer 66 years or older who were enrolled in fee-for-service Medicare and had no previous depression diagnosis. Long-term survivors were diagnosed with cancer between JaJAMA network opene2544812https://www.ebi.ac.uk/biostudies/studies/S-EPMC12658655biostudies-literatureRisk of Late-Onset Depression in Long-Term Survivors of Breast, Prostate, and Colorectal Cancer.PMC12658655Yasin FSpees LWang SYDinan MACecchini MOeffinger KGross CPTaylor MSilber ALeeds IWestvold SJHyslop TLeapman MSWheeler SBLong JBKwaramba TForman RfalseRisk of Late-Onset Depression in Long-Term Survivors of Breast, Prostate, and Colorectal Cancer.<h4>Importance</h4>The prevalence of depression is higher in cancer survivors than in the general population. As the long-term cancer survivor population increases, it is increasingly important to understand risk factors for late-onset depression.<h4>Objective</h4>To identify risk factors associated with late-onset depression in long-term (5-year) survivors of breast, prostate, or colorectal cancer.<h4>Design, setting, and participants</h4>This retrospective cohort study used 2022 linkage of Surveillance, Epidemiology, and End Results (SEER) and Medicare data to identify 5-year survivors of breast, prostate, or colorectal cancer 66 years or older who were enrolled in fee-for-service Medicare and had no previous depression diagnosis. Long-term survivors were diagnosed with cancer between Ja2025-01-01T00:00:00Z2025 Nov2026-06-05T20:35:39.586Z2026-05-21T03:12:54.418ZS-EPMC126586554129648510.1001/jamanetworkopen.2025.44812