biostudies-literatureUnknown15(1)Su BTo evaluate the synergistic predictive capacity of MRI lesion classification and serum CA125 for symptom manifestation (dysmenorrhea/menorrhagia) and explore associated adenomyosis pathogenesis. Patients before focused ultrasound ablation surgery were categorized into MRI-based severity group (Group A) and MRI-based non-severity group (Group B). Binary logistic regression was employed to identify the factors associating dysmenorrhea and CA125 level in total cohort and subgroups via MRI-based classifications criteria. The receiver-operating characteristic (ROC) curve was applied to assess the utility of CA125 for dysmenorrhea. Patients in dysmenorrhea subtype exhibited higher CA125 levels compared with those in non-dysmenorrhea subtype in total cohort and Group A (P < 0.05). Uterine volumesScientific reports42317https://www.ebi.ac.uk/biostudies/studies/S-EPMC12660971biostudies-literatureCombined magnetic resonance imaging with serum CA125 for dysmenorrhea in adenomyosis.PMC12660971Fang CLSu BLi JShi QYang MTHuang JRWang HHe HNHu HQZhu LJTang WJiang ZJTang YfalseCombined magnetic resonance imaging with serum CA125 for dysmenorrhea in adenomyosis.To evaluate the synergistic predictive capacity of MRI lesion classification and serum CA125 for symptom manifestation (dysmenorrhea/menorrhagia) and explore associated adenomyosis pathogenesis. Patients before focused ultrasound ablation surgery were categorized into MRI-based severity group (Group A) and MRI-based non-severity group (Group B). Binary logistic regression was employed to identify the factors associating dysmenorrhea and CA125 level in total cohort and subgroups via MRI-based classifications criteria. The receiver-operating characteristic (ROC) curve was applied to assess the utility of CA125 for dysmenorrhea. Patients in dysmenorrhea subtype exhibited higher CA125 levels compared with those in non-dysmenorrhea subtype in total cohort and Group A (P < 0.05). Uterine volumes2025-01-01T00:00:00Z2025 Nov2026-06-05T21:20:10.781Z2026-05-22T03:08:51.394ZS-EPMC126609714130974110.1038/s41598-025-26412-3