{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["122"],"submitter":["Liu M"],"pubmed_abstract":["<h4>Background</h4>Skeletal muscle-to-bone crosstalk may play critical roles in the association between muscle atrophy and bone loss. Here, we report a myokine, IL-33, which may mediate muscle-to-bone crosstalk.<h4>Methods</h4>A cohort study was conducted to elucidate the associations among circulating IL-33, osteoporosis, and sarcopenia in older adults. To delineate the role of IL-33 in muscle-to-bone crosstalk, we established rat models combining weighted-bearing exercise (WBE), botulinum neurotoxin A (BoNT/A)-induced muscle atrophy, and ovariectomy (OVX), and modulated muscle IL-33 levels both non-specifically and in a muscle-specific manner. Single-cell RNA sequencing was employed to identify the mechanisms by which IL-33 influences bone metabolism, and the downstream pathway was inter"],"journal":["EBioMedicine"],"pagination":["106024"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12661402"],"repository":["biostudies-literature"],"pubmed_title":["Skeletal muscle-derived IL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8&lt;sup&gt;+&lt;/sup&gt; T cell-secreted CCL5."],"pmcid":["PMC12661402"],"pubmed_authors":["Chu Q","Liu M","Zhu Y","Zhang Y","Han Y","Sun G","Wang J","Yang C","Chen B"],"additional_accession":[]},"is_claimable":false,"name":"Skeletal muscle-derived IL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8&lt;sup&gt;+&lt;/sup&gt; T cell-secreted CCL5.","description":"<h4>Background</h4>Skeletal muscle-to-bone crosstalk may play critical roles in the association between muscle atrophy and bone loss. Here, we report a myokine, IL-33, which may mediate muscle-to-bone crosstalk.<h4>Methods</h4>A cohort study was conducted to elucidate the associations among circulating IL-33, osteoporosis, and sarcopenia in older adults. To delineate the role of IL-33 in muscle-to-bone crosstalk, we established rat models combining weighted-bearing exercise (WBE), botulinum neurotoxin A (BoNT/A)-induced muscle atrophy, and ovariectomy (OVX), and modulated muscle IL-33 levels both non-specifically and in a muscle-specific manner. Single-cell RNA sequencing was employed to identify the mechanisms by which IL-33 influences bone metabolism, and the downstream pathway was inter","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T20:46:42.392Z","creation":"2026-05-21T03:13:03.89Z"},"accession":"S-EPMC12661402","cross_references":{"pubmed":["41237669"],"doi":["10.1016/j.ebiom.2025.106024"]}}