biostudies-literatureUnknown25(1)Guo L<h4>Background</h4>This study aims to examine the relationship between the serum uric acid-to-high density lipoprotein cholesterol ratio (UHR) and short-term readmission risk in patients with heart failure.<h4>Methods</h4>In this retrospective cohort study, we analyzed clinical data from Zigong Fourth People's Hospital (December 2016 to June 2019) using multivariate logistic regression, restricted cubic splines, and subgroup analyses to examine the independent association between UHR and short-term readmission risk.<h4>Results</h4>The analysis included 1795 participants, of whom 58.4% were female and 53.7% were aged 60-79 years. Our study showed that an increase of one unit in the UHR was associated with a 275% increase in 28-day readmission risk (OR = 3.75, 95% CI = 1.56-9.01, P = 0.003) BMC cardiovascular disorders850https://www.ebi.ac.uk/biostudies/studies/S-EPMC12661802biostudies-literatureNonlinear relationship between the serum uric acid-to-high density lipoprotein cholesterol ratio and short-term readmission in chronic heart failure: a retrospective cohort study.PMC12661802Guo LLiu PCai LHu LZhou YfalseNonlinear relationship between the serum uric acid-to-high density lipoprotein cholesterol ratio and short-term readmission in chronic heart failure: a retrospective cohort study.<h4>Background</h4>This study aims to examine the relationship between the serum uric acid-to-high density lipoprotein cholesterol ratio (UHR) and short-term readmission risk in patients with heart failure.<h4>Methods</h4>In this retrospective cohort study, we analyzed clinical data from Zigong Fourth People's Hospital (December 2016 to June 2019) using multivariate logistic regression, restricted cubic splines, and subgroup analyses to examine the independent association between UHR and short-term readmission risk.<h4>Results</h4>The analysis included 1795 participants, of whom 58.4% were female and 53.7% were aged 60-79 years. Our study showed that an increase of one unit in the UHR was associated with a 275% increase in 28-day readmission risk (OR = 3.75, 95% CI = 1.56-9.01, P = 0.003) 2025-01-01T00:00:00Z2025 Nov2026-06-05T20:27:46.535Z2026-05-21T03:12:30.821ZS-EPMC126618024131597810.1186/s12872-025-05197-3