{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang P"],"funding":["Natural Science Foundation of Chongqing Municipality","National Natural Science Foundation of China"],"pagination":["284-304"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12661998"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["57"],"pubmed_abstract":["The bone unit (BU) is a multicellular functional unit composed of neuromodulatory networks, bone tissue, and functional blood vessels. As a functional extension of bone regeneration, the BU coordinates neural signal, regeneration of the circulatory network and remodeling of the bone matrix through the neural-bone metabolic coupling mechanism. Currently, effective strategies are lacking to remodel the homeostasis of the neural-bone metabolic coupling, which in turn leads to impaired BU regeneration. Here, we constructed a 3D-printed biomimetic hydrogel scaffold, GGMN-GSE, to synergistically couple nerve-bone metabolism and restore BU regeneration through electrophysiological microenvironment reconstruction and functional cell recruitment. The GGMN layer (Grooved GelMA@MXene@NGF) incorporate"],"journal":["Bioactive materials"],"pubmed_title":["3D printed scaffolds regulated by neural-bone metabolic coupling promote bone unit regeneration."],"pmcid":["PMC12661998"],"funding_grant_id":["82472404","W2411085","CSTB2022NSCQ-MSX0104"],"pubmed_authors":["Yang H","Jiang K","Li Y","Cao X","Lei Y","Zhang H","Cui W","Yan C","Li L","Lai N","Zhang P"],"additional_accession":[]},"is_claimable":false,"name":"3D printed scaffolds regulated by neural-bone metabolic coupling promote bone unit regeneration.","description":"The bone unit (BU) is a multicellular functional unit composed of neuromodulatory networks, bone tissue, and functional blood vessels. As a functional extension of bone regeneration, the BU coordinates neural signal, regeneration of the circulatory network and remodeling of the bone matrix through the neural-bone metabolic coupling mechanism. Currently, effective strategies are lacking to remodel the homeostasis of the neural-bone metabolic coupling, which in turn leads to impaired BU regeneration. Here, we constructed a 3D-printed biomimetic hydrogel scaffold, GGMN-GSE, to synergistically couple nerve-bone metabolism and restore BU regeneration through electrophysiological microenvironment reconstruction and functional cell recruitment. The GGMN layer (Grooved GelMA@MXene@NGF) incorporate","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Mar","modification":"2026-06-05T21:23:01.359Z","creation":"2026-05-22T03:08:49.068Z"},"accession":"S-EPMC12661998","cross_references":{"pubmed":["41323200"],"doi":["10.1016/j.bioactmat.2025.10.031"]}}