{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Miao L"],"funding":["NEI NIH HHS","American Heart Association-American Stroke Association","NHLBI NIH HHS","NINDS NIH HHS","NIAMS NIH HHS","NIGMS NIH HHS"],"pagination":["eadd3417"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12662173"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["387(6739)"],"pubmed_abstract":["In the developing mammalian heart, the endocardium and the myocardium are separated by so-called cardiac jelly. Communication between the endocardium and the myocardium is essential for cardiac morphogenesis. How membrane-localized receptors and ligands achieve interaction across the cardiac jelly is not understood. Working in developing mouse cardiac morphogenesis models, we used a variety of cellular, imaging, and genetic approaches to elucidate this question. We found that myocardium and endocardium interacted directly through microstructures termed tunneling nanotube-like structures (TNTLs). TNTLs extended from cardiomyocytes (CMs) to contact endocardial cells (ECs) directly. TNTLs transported cytoplasmic proteins, transduced signals between CMs and ECs, and initiated myocardial growth"],"journal":["Science (New York, N.Y.)"],"pubmed_title":["Tunneling nanotube-like structures regulate distant cellular interactions during heart formation."],"pmcid":["PMC12662173"],"funding_grant_id":["R01 HL121700","R01 HL172834","P30 EY007551","R35 GM153178","25EIA1422015","R01 GM072804","R01 GM143223","R01 AR081487","R21 NS138590"],"pubmed_authors":["Zheng Y","Wu M","Lu Y","Schwartz RJ","Sui H","Fan ZC","Serysheva II","Miao L","Zhang S","Liu Y","Fan G","Zhao L","Wu CL","Guo H","Zhou B","Huyen TLN","Nusrat A","Burns AR","Evans SM","Shou W","Kumar A","Wan LQ"],"additional_accession":[]},"is_claimable":false,"name":"Tunneling nanotube-like structures regulate distant cellular interactions during heart formation.","description":"In the developing mammalian heart, the endocardium and the myocardium are separated by so-called cardiac jelly. Communication between the endocardium and the myocardium is essential for cardiac morphogenesis. How membrane-localized receptors and ligands achieve interaction across the cardiac jelly is not understood. Working in developing mouse cardiac morphogenesis models, we used a variety of cellular, imaging, and genetic approaches to elucidate this question. We found that myocardium and endocardium interacted directly through microstructures termed tunneling nanotube-like structures (TNTLs). TNTLs extended from cardiomyocytes (CMs) to contact endocardial cells (ECs) directly. TNTLs transported cytoplasmic proteins, transduced signals between CMs and ECs, and initiated myocardial growth","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-06-06T21:15:46.27Z","creation":"2026-06-05T03:11:51.48Z"},"accession":"S-EPMC12662173","cross_references":{"pubmed":["40080583"],"doi":["10.1126/science.add3417"]}}