{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(1)"],"submitter":["Chatzigeorgiou C"],"pubmed_abstract":["<h4>Background</h4>Autism spectrum disorder (ASD) shows significant clinical variability, likely due to a combination of genetic and environmental factors. Preterm birth is a known risk factor for ASD, occurring in approximately 13% of diagnosed individuals. While genetic factors contribute to preterm birth in the general population, the relationship between genetic variation, preterm birth, and ASD heterogeneity remains unclear.<h4>Methods</h4>We investigated the genetic factors associated with preterm birth in 31,947 autistic individuals using data from the SPARK (Simons Foundation Powering Autism Research for Knowledge) sample. We conducted 3 ancestry-specific genome-wide association studies for African/African American, admixed American, and non-Finnish European ancestries, followed by"],"journal":["Biological psychiatry global open science"],"pagination":["100614"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12662992"],"repository":["biostudies-literature"],"pubmed_title":["Autism Heterogeneity Related to Preterm Birth: Multi-Ancestry Results From the Simons Foundation Powering Autism Research for Knowledge Sample."],"pmcid":["PMC12662992"],"pubmed_authors":["Chatzigeorgiou C","Mullins N","Mahjani B","Khachadourian V","Souaiaia T","Asgel Z","Janecka M","Avila MN"],"additional_accession":[]},"is_claimable":false,"name":"Autism Heterogeneity Related to Preterm Birth: Multi-Ancestry Results From the Simons Foundation Powering Autism Research for Knowledge Sample.","description":"<h4>Background</h4>Autism spectrum disorder (ASD) shows significant clinical variability, likely due to a combination of genetic and environmental factors. Preterm birth is a known risk factor for ASD, occurring in approximately 13% of diagnosed individuals. While genetic factors contribute to preterm birth in the general population, the relationship between genetic variation, preterm birth, and ASD heterogeneity remains unclear.<h4>Methods</h4>We investigated the genetic factors associated with preterm birth in 31,947 autistic individuals using data from the SPARK (Simons Foundation Powering Autism Research for Knowledge) sample. We conducted 3 ancestry-specific genome-wide association studies for African/African American, admixed American, and non-Finnish European ancestries, followed by","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-05T20:33:45.723Z","creation":"2026-05-21T03:12:47.244Z"},"accession":"S-EPMC12662992","cross_references":{"pubmed":["41321420"],"doi":["10.1016/j.bpsgos.2025.100614"]}}