biostudies-literatureYou YFoundation Topconsortium voor Kennis en Innovatie (TKI) Horticulture & Starting Materials funderDoi="10.13039/501100020068"5710-5727https://www.ebi.ac.uk/biostudies/studies/S-EPMC12665072biostudies-literatureUnknown23(12)The infection of plants by pathogens is an intricate process in which genes from both the host and pathogen contribute to the infection process. Susceptibility (S) genes have been defined as plant genes that encode functions that are exploited by pathogens to invade and reproduce in host plants. Mutations in S-genes therefore result in reduced susceptibility to the pathogen. The identity and mode of action of S-genes in interactions of plants with biotrophic fungi have been studied since the cloning of the barley mlo gene in the late 1990s. The infection strategy of necrotrophic fungi, however, substantially differs from that of biotrophic fungi and therefore is likely to be facilitated by distinct physiological processes in a host plant. There is a rapidly increasing amount of informationPlant biotechnology journalWinning by Losing: Exploiting Modified Plant Susceptibility Genes to Counteract Necrotrophic Fungal Pathogens.PMC12665072TU-18015You Yvan Kan JALWolters AARamirez Gaona MBai YfalseWinning by Losing: Exploiting Modified Plant Susceptibility Genes to Counteract Necrotrophic Fungal Pathogens.The infection of plants by pathogens is an intricate process in which genes from both the host and pathogen contribute to the infection process. Susceptibility (S) genes have been defined as plant genes that encode functions that are exploited by pathogens to invade and reproduce in host plants. Mutations in S-genes therefore result in reduced susceptibility to the pathogen. The identity and mode of action of S-genes in interactions of plants with biotrophic fungi have been studied since the cloning of the barley mlo gene in the late 1990s. The infection strategy of necrotrophic fungi, however, substantially differs from that of biotrophic fungi and therefore is likely to be facilitated by distinct physiological processes in a host plant. There is a rapidly increasing amount of information2025-01-01T00:00:00Z2025 Dec2026-06-05T21:07:55.631Z2026-05-21T03:13:04.742ZS-EPMC126650724085376410.1111/pbi.70331