{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(1)"],"submitter":["Huang J"],"pubmed_abstract":["<b>Background:</b> Osteoporosis is a major public health concern worldwide. As the predominant and long-lived bone cells, osteocytes serve as key regulators of bone remodeling and mechanotransduction. However, the molecular mechanisms underlying their regulatory roles remain poorly understood. The roles of talin1, a key focal adhesion protein linking integrins to the cytoskeleton, in regulation of osteocyte function and skeletal homeostasis remain unclear. <b>Methods:</b> Osteocyte-specific talin1 conditional knockout (cKO) mice were established, and their skeletal phenotypes were assessed through micro-CT, histomorphometry, and biomechanical analyses. Osteocyte senescence and molecular signaling were assessed by RNA sequencing analysis, immunostaining, and biochemical assays. Talin1-p53 i"],"journal":["Theranostics"],"pagination":["465-482"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12665141"],"repository":["biostudies-literature"],"pubmed_title":["The talin1-p53 axis inhibits osteocyte senescence to promote bone mass and mediate skeletal adaptation to mechanical stimulation."],"pmcid":["PMC12665141"],"pubmed_authors":["Yang H","Wu M","Yang J","Qin L","Yan Q","Lin S","Huang J","Chen H","Yi W","Gong W","Zhang P","He S","Zhang X","Xiao G","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"The talin1-p53 axis inhibits osteocyte senescence to promote bone mass and mediate skeletal adaptation to mechanical stimulation.","description":"<b>Background:</b> Osteoporosis is a major public health concern worldwide. As the predominant and long-lived bone cells, osteocytes serve as key regulators of bone remodeling and mechanotransduction. However, the molecular mechanisms underlying their regulatory roles remain poorly understood. The roles of talin1, a key focal adhesion protein linking integrins to the cytoskeleton, in regulation of osteocyte function and skeletal homeostasis remain unclear. <b>Methods:</b> Osteocyte-specific talin1 conditional knockout (cKO) mice were established, and their skeletal phenotypes were assessed through micro-CT, histomorphometry, and biomechanical analyses. Osteocyte senescence and molecular signaling were assessed by RNA sequencing analysis, immunostaining, and biochemical assays. Talin1-p53 i","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026","modification":"2026-07-15T13:25:13.691Z","creation":"2026-07-05T03:08:30.2Z"},"accession":"S-EPMC12665141","cross_references":{"pubmed":["41328350"],"doi":["10.7150/thno.123532"]}}