{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cardozo PL"],"funding":["Fundação de Amparo à Pesquisa do Estado de Minas Gerais","Conselho Nacional de Desenvolvimento Científico e Tecnológico"],"pagination":["e70085"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12666992"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["74(1)"],"pubmed_abstract":["Neuroinflammation, particularly astrocyte reactivity, is increasingly linked to schizophrenia (SCZ). Yet, the crosstalk between astrocytes and microglia in SCZ, especially under pro-inflammatory conditions, remains unclear. Here, we employed human induced-pluripotent stem cells to compare how astrocytes from five age-matched individuals with SCZ and five neurotypical controls, upon stimulation with TNF-α, affected microglial biology. TNF-α stimulation of SCZ astrocytes, relative to their control counterparts, triggered increased mRNA expression of pro-inflammatory cytokines and CX3CL1. Interestingly, transcriptomic and gene set enrichment analyses revealed that reactive SCZ astrocytes promoted the downregulation of biological processes associated with immune cell proliferation and activati"],"journal":["Glia"],"pubmed_title":["hiPSC-Derived Astrocytes From Individuals With Schizophrenia Induce a Dystrophic Phenotype in Microglial-Like Cells."],"pmcid":["PMC12666992"],"funding_grant_id":["APQ‐00140‐23","444206/2024-8","406968/2024‐1","APQ-00140-23","444206/2024‐8","APQ‐03921‐22","406968/2024-1","APQ-03921-22","BPD‐00067‐22","403171/2023-7","BPD-00067-22","403171/2023‐7"],"pubmed_authors":["Bonamino MH","Cruz BF","Chicaybam L","Brennand KJ","Cardozo PL","Lee CY","de Faria IJS","Vitoria G","Cordeiro RC","Todjro YMH","Fahel JS","Silva NC","Maciel JCDP","Trindade P","Rehen SK","Nicolato R","Lacerda JPS","Vieira LB","Ribeiro FM"],"additional_accession":[]},"is_claimable":false,"name":"hiPSC-Derived Astrocytes From Individuals With Schizophrenia Induce a Dystrophic Phenotype in Microglial-Like Cells.","description":"Neuroinflammation, particularly astrocyte reactivity, is increasingly linked to schizophrenia (SCZ). Yet, the crosstalk between astrocytes and microglia in SCZ, especially under pro-inflammatory conditions, remains unclear. Here, we employed human induced-pluripotent stem cells to compare how astrocytes from five age-matched individuals with SCZ and five neurotypical controls, upon stimulation with TNF-α, affected microglial biology. TNF-α stimulation of SCZ astrocytes, relative to their control counterparts, triggered increased mRNA expression of pro-inflammatory cytokines and CX3CL1. Interestingly, transcriptomic and gene set enrichment analyses revealed that reactive SCZ astrocytes promoted the downregulation of biological processes associated with immune cell proliferation and activati","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-05T20:39:37.495Z","creation":"2026-05-21T03:13:02.043Z"},"accession":"S-EPMC12666992","cross_references":{"pubmed":["40970468"],"doi":["10.1002/glia.70085"]}}