biostudies-literatureUnknown20(12)Nama NAmerican Academy of Pediatrics/Resident Research Grant Program 2021Alberta Children's Hospital FoundationSeattle Children's Research Institute/Career Development Award 2023-2026University of CalgaryAmerican Academy of PediatricsBC Children's Hospital/Early Investigator Seeds Grant 2022<h4>Background</h4>Guidelines on Brief Resolved Unexplained Event (BRUE) only provide recommendations for infants categorized at lower risk. However, most infants fall into the higher-risk category, leaving management decisions to individual clinicians and contributing to variation in care.<h4>Objectives</h4>Describe interhospital variation in BRUE management and determine whether higher resource utilization improves detection of serious underlying diagnoses.<h4>Methods</h4>This multicenter observational cohort (2017-2021) included infants (< 12 months) with BRUE at eight Canadian hospitals. We recorded admission, and use of electrocardiograms (ECG), electroencephalograms (EEG), antibiotic and anti-reflux medications, and subspecialty consultations. Multivariable median regression evaluateJournal of hospital medicine1297-1305https://www.ebi.ac.uk/biostudies/studies/S-EPMC12666994biostudies-literatureInterhospital variation in the management of Brief Resolved Unexplained Events (BRUE) in infants: A Canadian multicenter cohort study.PMC12666994Picco KFoulds JLBone JNKanani RHolland JParisien BQuet JGagnon JATieder JSKyrychenko PGill PJCoon ESehgal ANama NCanadian BRUE Collaboration (C‐BRUE‐C) and the Canadian Paediatric Inpatient Research Network (PIRN)Goldman RDDonlan MNovak CMahant SfalseInterhospital variation in the management of Brief Resolved Unexplained Events (BRUE) in infants: A Canadian multicenter cohort study.<h4>Background</h4>Guidelines on Brief Resolved Unexplained Event (BRUE) only provide recommendations for infants categorized at lower risk. However, most infants fall into the higher-risk category, leaving management decisions to individual clinicians and contributing to variation in care.<h4>Objectives</h4>Describe interhospital variation in BRUE management and determine whether higher resource utilization improves detection of serious underlying diagnoses.<h4>Methods</h4>This multicenter observational cohort (2017-2021) included infants (< 12 months) with BRUE at eight Canadian hospitals. We recorded admission, and use of electrocardiograms (ECG), electroencephalograms (EEG), antibiotic and anti-reflux medications, and subspecialty consultations. Multivariable median regression evaluate2025-01-01T00:00:00Z2025 Dec2026-06-05T21:52:16.542Z2026-05-22T03:15:54.436ZS-EPMC126669944057199610.1002/jhm.70094