{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Gaglani M"],"funding":["Kaiser Permanente Washington Research Institute","University of Michigan","NCATS NIH HHS","NCRR NIH HHS","Baylor Scott &amp; White Health","University of Pittsburgh","Marshfield Clinic Research Institute","US Centers for Disease Control and Prevention","NCIRD CDC HHS","Intramural CDC HHS"],"pubmed_abstract":["<h4>Background</h4>Estimates of annual effectiveness of influenza vaccination combine multiple vaccine types. Reports of brand/product-specific vaccine effectiveness (VE) of egg- and cell-culture based quadrivalent inactivated influenza vaccines (IIV4/ccIIV4) are limited.<h4>Methods</h4>Using an observational test-negative study design, we compared effectiveness of selected IIV4 and ccIIV4 products among outpatients enrolled in the US Flu VE Network from 2014-2015 to 2018-2019. We used multivariable logistic regression to estimate product- and age-group-specific absolute and relative effectiveness of recommended, age-appropriate vaccines against symptomatic laboratory-confirmed outpatient influenza. Relative effectiveness of ccIIV4 versus IIV4 products was estimated during two seasons from"],"journal":["Clinical infectious diseases : an official publication of the Infectious Diseases Society of America"],"pagination":["ciaf579"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12667161"],"repository":["biostudies-literature"],"pubmed_title":["Absolute and Relative Effectiveness of Cell- and Egg-based Quadrivalent Inactivated Influenza Vaccine Products from 2014-2015 to 2018-2019 seasons, U.S. Flu VE Network."],"pmcid":["PMC12667161"],"funding_grant_id":["U01 IP000471","UL1 TR000005","UL1 TR001857","U01 IP000466","U01 IP001039","U01 IP001037","CC999999","U01 IP000467","U01 IP001038","U01 IP000473","U01 IP001035","U01 IP001034","U01 IP000474","UL1 RR024153"],"pubmed_authors":["Phillips CH","Kim SS","Chung JR","Murthy K","Zimmerman RK","Nguyen HQ","Gaglani M","Dubrocq G","Martin ET","Raiyani C","King JP","Smith M","Monto AS","Nowalk MP","Beeram M","Kiniry E","Flannery B","da Graca B"],"additional_accession":[]},"is_claimable":false,"name":"Absolute and Relative Effectiveness of Cell- and Egg-based Quadrivalent Inactivated Influenza Vaccine Products from 2014-2015 to 2018-2019 seasons, U.S. Flu VE Network.","description":"<h4>Background</h4>Estimates of annual effectiveness of influenza vaccination combine multiple vaccine types. Reports of brand/product-specific vaccine effectiveness (VE) of egg- and cell-culture based quadrivalent inactivated influenza vaccines (IIV4/ccIIV4) are limited.<h4>Methods</h4>Using an observational test-negative study design, we compared effectiveness of selected IIV4 and ccIIV4 products among outpatients enrolled in the US Flu VE Network from 2014-2015 to 2018-2019. We used multivariable logistic regression to estimate product- and age-group-specific absolute and relative effectiveness of recommended, age-appropriate vaccines against symptomatic laboratory-confirmed outpatient influenza. Relative effectiveness of ccIIV4 versus IIV4 products was estimated during two seasons from","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-06T07:10:29.952Z","creation":"2026-06-06T03:06:21.517Z"},"accession":"S-EPMC12667161","cross_references":{"pubmed":["41102880"],"doi":["10.1093/cid/ciaf579"]}}