{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Seemiller LR"],"funding":["Pennsylvania State University","NIDA NIH HHS","National Institute on Drug Abuse","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["2022-2034"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12667965"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["48(11)"],"pubmed_abstract":["<h4>Background</h4>Adolescent sensitivity to alcohol is influenced by genetic background. Data from our laboratory suggested that adolescent C57BL/6J and DBA/2J inbred mice differed in susceptibility to alcohol-induced deficits in dorsal hippocampus-dependent contextual fear learning.<h4>Methods</h4>To investigate the biological underpinnings of this strain difference, we examined dorsal hippocampus gene expression using RNA-sequencing after alcohol or saline administration followed by Pavlovian fear conditioning across male and female C57BL/6J and DBA/2J adolescents.<h4>Results</h4>Strains exhibited dramatic differences in dorsal hippocampus gene expression. Specifically, C57BL/6J and DBA/2J strains differed by 3526 transcripts in males and 2675 transcripts in females. We identified pathw"],"journal":["Alcohol, clinical & experimental research"],"pubmed_title":["Alcohol and fear conditioning produce strain-specific changes in the dorsal hippocampal transcriptome of adolescent C57BL/6J and DBA/2J mice."],"pmcid":["PMC12667965"],"funding_grant_id":["T32 GM108563","R01 DA044339","U01DA041632","U01 DA041632","T32GM108563","U01DA044339"],"pubmed_authors":["Seemiller LR","Praul C","Siegel SR","Albert I","Goldberg LR","Bryant CD","Beierle J","Sebastian A","Zeid D","Gould TJ"],"additional_accession":[]},"is_claimable":false,"name":"Alcohol and fear conditioning produce strain-specific changes in the dorsal hippocampal transcriptome of adolescent C57BL/6J and DBA/2J mice.","description":"<h4>Background</h4>Adolescent sensitivity to alcohol is influenced by genetic background. Data from our laboratory suggested that adolescent C57BL/6J and DBA/2J inbred mice differed in susceptibility to alcohol-induced deficits in dorsal hippocampus-dependent contextual fear learning.<h4>Methods</h4>To investigate the biological underpinnings of this strain difference, we examined dorsal hippocampus gene expression using RNA-sequencing after alcohol or saline administration followed by Pavlovian fear conditioning across male and female C57BL/6J and DBA/2J adolescents.<h4>Results</h4>Strains exhibited dramatic differences in dorsal hippocampus gene expression. Specifically, C57BL/6J and DBA/2J strains differed by 3526 transcripts in males and 2675 transcripts in females. We identified pathw","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-07-02T03:17:06.663Z","creation":"2026-07-02T03:09:02.516Z"},"accession":"S-EPMC12667965","cross_references":{"pubmed":["39279663"],"doi":["10.1111/acer.15440"]}}