{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Campbell IW"],"funding":["NIDDK NIH HHS","NIAID NIH HHS","Howard Hughes Medical Institute (HHMI)"],"pagination":["3069-3074"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12669028"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(12)"],"pubmed_abstract":["The natural context in which CRISPR-Cas systems are active in Enterobacteriaceae has remained enigmatic. Here we find that the Citrobacter rodentium type I-E CRISPR-Cas system is activated by the oxygen-responsive transcriptional regulator Fnr in the anoxic environment of the mouse intestine. Since Fnr-dependent regulation is predicted in ~41% of Enterobacteriaceae cas3 orthologues, we propose that anoxic regulation of CRISPR-Cas immunity is an adaptation that protects Enterobacteriaceae against threats from foreign DNA within the intestinal microbiome."],"journal":["Nature microbiology"],"pubmed_title":["Anoxia activates CRISPR-Cas immunity in the mouse intestine."],"pmcid":["PMC12669028"],"funding_grant_id":["R01 AI042347","P30 DK034854","Investigator program"],"pubmed_authors":["Waldor MK","Basta DW","Zingl FG","Doranga S","Sullivan EJ","Campbell IW"],"additional_accession":[]},"is_claimable":false,"name":"Anoxia activates CRISPR-Cas immunity in the mouse intestine.","description":"The natural context in which CRISPR-Cas systems are active in Enterobacteriaceae has remained enigmatic. Here we find that the Citrobacter rodentium type I-E CRISPR-Cas system is activated by the oxygen-responsive transcriptional regulator Fnr in the anoxic environment of the mouse intestine. Since Fnr-dependent regulation is predicted in ~41% of Enterobacteriaceae cas3 orthologues, we propose that anoxic regulation of CRISPR-Cas immunity is an adaptation that protects Enterobacteriaceae against threats from foreign DNA within the intestinal microbiome.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-05T21:48:49.811Z","creation":"2026-05-22T03:16:12.309Z"},"accession":"S-EPMC12669028","cross_references":{"pubmed":["41162659"],"doi":["10.1038/s41564-025-02172-8"]}}