{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gu S"],"funding":["The National Key Research and Development Program of China","The National Science Foundation of Zhejiang Province","The National Natural Science Foundation of China","Hangzhou West Lake Pearl Project Leading Innovative Youth Team Project"],"pagination":["7154-7180"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12669696"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(23)"],"pubmed_abstract":["FAM134/RETREG family members are ER-phagy receptors that maintain cellular homeostasis by regulating endoplasmic reticulum turnover. However, possible non-ER-phagy functions of FAM134 proteins remain elusive. Here, we show that RETREG3/FAM134C functions as a selective autophagy receptor for the type I BMP receptor (BMPRIA/ALK3) and recruits BMPRIA into LC3-containing autophagosomes for subsequent degradation. FAM134C-induced degradation diminishes the availability of BMP receptors and thus the strength of BMP signaling. Inhibition of autophagy through chemical means or knockdown of key autophagy regulators, ATG5 or Beclin-1, prevents BMPR1A degradation. Additionally, disruption of the putative LC3-interacting region (LIR) motif in FAM134C completely abolishes its interaction with LC3, ther"],"journal":["The EMBO journal"],"pubmed_title":["Reticulophagy receptor FAM134C restrains BMP receptor signaling."],"pmcid":["PMC12669696"],"funding_grant_id":["31771546","31730057","LD21C070001","2022YFC3401500","LZ22C070001","TD2023017","32321002","U21A20356"],"pubmed_authors":["Wu J","Gu S","Xu P","Zhao B","Cao J","Zhang H","Lin X","Liu T","Liu X","Feng XH","He Z","Sun Q","Zheng M","Han J","Jin J","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"Reticulophagy receptor FAM134C restrains BMP receptor signaling.","description":"FAM134/RETREG family members are ER-phagy receptors that maintain cellular homeostasis by regulating endoplasmic reticulum turnover. However, possible non-ER-phagy functions of FAM134 proteins remain elusive. Here, we show that RETREG3/FAM134C functions as a selective autophagy receptor for the type I BMP receptor (BMPRIA/ALK3) and recruits BMPRIA into LC3-containing autophagosomes for subsequent degradation. FAM134C-induced degradation diminishes the availability of BMP receptors and thus the strength of BMP signaling. Inhibition of autophagy through chemical means or knockdown of key autophagy regulators, ATG5 or Beclin-1, prevents BMPR1A degradation. Additionally, disruption of the putative LC3-interacting region (LIR) motif in FAM134C completely abolishes its interaction with LC3, ther","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-07-15T14:35:42.318Z","creation":"2026-07-06T03:08:10.554Z"},"accession":"S-EPMC12669696","cross_references":{"pubmed":["41116059"],"doi":["10.1038/s44318-025-00581-3"]}}