{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(12)"],"submitter":["Xie F"],"pubmed_abstract":["<h4>Importance</h4>Pantoprazole reduces clinically important upper gastrointestinal bleeding in critically ill patients. However, the cost-effectiveness of this strategy is unclear.<h4>Objective</h4>To assess the cost-effectiveness of daily intravenous pantoprazole vs no pantoprazole for preventing upper gastrointestinal bleeding in mechanically ventilated patients.<h4>Design, setting, and participants</h4>This prospective health economic evaluation was conducted alongside the Reevaluating the Inhibition of Stress Erosions (REVISE) trial over a time horizon of intensive care unit (ICU) admission to hospital discharge or death from a public health care payer's perspective. The REVISE trial included critically ill adults from Canada, Australia, the US, England, Saudi Arabia, Brazil, Kuwait, "],"journal":["JAMA network open"],"pagination":["e2552771"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12670189"],"repository":["biostudies-literature"],"pubmed_title":["Cost-Effectiveness of Pantoprazole to Prevent Upper Gastrointestinal Bleeding in Mechanically Ventilated Patients."],"pmcid":["PMC12670189"],"pubmed_authors":["Mele T","Marshall JC","Fowler R","St Arnaud C","Meade M","Niven D","Reis G","Saunders L","Dionne J","Sy E","Ovakim D","Hammond N","Xie F","Arabi YM","Goffi A","Adhikari N","E-REVISE Collaborators and the Canadian Critical Care Trials Group","Billot L","Johnson DW","Mehta S","Hand L","Barletta JF","English S","Hardie M","Thabane L","Rahman A","Poole A","Ball I","Trop S","Ostermann M","Hosek P","Archambault P","Hall R","Khwaja K","Young P","Charbonney E","Zarychanski R","Tsang JL","Myburgh J","Venkatesh B","Iqbal M","Lauzier F","Muscedere J","Rochwerg B","Cook DJ","Burns KEA","Henderson W","Geagea A","Fiest K","Ma Y","Al-Fares A","Forrest D","Humphries B","Lamontagne F","Alhazzani W","Knowles S","Marquis F","Rajbhandari D","Yao Y","Kanji S","Williamson D","Byrne KM","Binnie A","D'Aragon F","Cirone R","Kristof AS","Karachi T","Reeve B","Morgan I","Vanstone M","Wilcox ME","Loubani O","Duan E","Reynolds S","Burry L","Lau VI","Wood G","Deane A","Clarke F","Cavayas A","Dennis B","Rewa O","Tutschka M","Zytaruk N","Finfer S","Lellouche F","Heels-Ansdell D","Vazquez-Grande G","Guyatt GH","Chapman M"],"additional_accession":[]},"is_claimable":false,"name":"Cost-Effectiveness of Pantoprazole to Prevent Upper Gastrointestinal Bleeding in Mechanically Ventilated Patients.","description":"<h4>Importance</h4>Pantoprazole reduces clinically important upper gastrointestinal bleeding in critically ill patients. However, the cost-effectiveness of this strategy is unclear.<h4>Objective</h4>To assess the cost-effectiveness of daily intravenous pantoprazole vs no pantoprazole for preventing upper gastrointestinal bleeding in mechanically ventilated patients.<h4>Design, setting, and participants</h4>This prospective health economic evaluation was conducted alongside the Reevaluating the Inhibition of Stress Erosions (REVISE) trial over a time horizon of intensive care unit (ICU) admission to hospital discharge or death from a public health care payer's perspective. The REVISE trial included critically ill adults from Canada, Australia, the US, England, Saudi Arabia, Brazil, Kuwait, ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-05T21:53:02.864Z","creation":"2026-05-22T03:16:08.536Z"},"accession":"S-EPMC12670189","cross_references":{"pubmed":["41324956"],"doi":["10.1001/jamanetworkopen.2025.52771"]}}