biostudies-literatureUnknown8(12)Xie F<h4>Importance</h4>Pantoprazole reduces clinically important upper gastrointestinal bleeding in critically ill patients. However, the cost-effectiveness of this strategy is unclear.<h4>Objective</h4>To assess the cost-effectiveness of daily intravenous pantoprazole vs no pantoprazole for preventing upper gastrointestinal bleeding in mechanically ventilated patients.<h4>Design, setting, and participants</h4>This prospective health economic evaluation was conducted alongside the Reevaluating the Inhibition of Stress Erosions (REVISE) trial over a time horizon of intensive care unit (ICU) admission to hospital discharge or death from a public health care payer's perspective. The REVISE trial included critically ill adults from Canada, Australia, the US, England, Saudi Arabia, Brazil, Kuwait, JAMA network opene2552771https://www.ebi.ac.uk/biostudies/studies/S-EPMC12670189biostudies-literatureCost-Effectiveness of Pantoprazole to Prevent Upper Gastrointestinal Bleeding in Mechanically Ventilated Patients.PMC12670189Mele TMarshall JCFowler RSt Arnaud CMeade MNiven DReis GSaunders LDionne JSy EOvakim DHammond NXie FArabi YMGoffi AAdhikari NE-REVISE Collaborators and the Canadian Critical Care Trials GroupBillot LJohnson DWMehta SHand LBarletta JFEnglish SHardie MThabane LRahman APoole ABall ITrop SOstermann MHosek PArchambault PHall RKhwaja KYoung PCharbonney EZarychanski RTsang JLMyburgh JVenkatesh BIqbal MLauzier FMuscedere JRochwerg BCook DJBurns KEAHenderson WGeagea AFiest KMa YAl-Fares AForrest DHumphries BLamontagne FAlhazzani WKnowles SMarquis FRajbhandari DYao YKanji SWilliamson DByrne KMBinnie AD'Aragon FCirone RKristof ASKarachi TReeve BMorgan IVanstone MWilcox MELoubani ODuan EReynolds SBurry LLau VIWood GDeane AClarke FCavayas ADennis BRewa OTutschka MZytaruk NFinfer SLellouche FHeels-Ansdell DVazquez-Grande GGuyatt GHChapman MfalseCost-Effectiveness of Pantoprazole to Prevent Upper Gastrointestinal Bleeding in Mechanically Ventilated Patients.<h4>Importance</h4>Pantoprazole reduces clinically important upper gastrointestinal bleeding in critically ill patients. However, the cost-effectiveness of this strategy is unclear.<h4>Objective</h4>To assess the cost-effectiveness of daily intravenous pantoprazole vs no pantoprazole for preventing upper gastrointestinal bleeding in mechanically ventilated patients.<h4>Design, setting, and participants</h4>This prospective health economic evaluation was conducted alongside the Reevaluating the Inhibition of Stress Erosions (REVISE) trial over a time horizon of intensive care unit (ICU) admission to hospital discharge or death from a public health care payer's perspective. The REVISE trial included critically ill adults from Canada, Australia, the US, England, Saudi Arabia, Brazil, Kuwait, 2025-01-01T00:00:00Z2025 Dec2026-06-05T21:53:02.864Z2026-05-22T03:16:08.536ZS-EPMC126701894132495610.1001/jamanetworkopen.2025.52771