{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Thaweethai T"],"funding":["NHLBI NIH HHS"],"pagination":["127907"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12670331"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["68"],"pubmed_abstract":["<h4>Purpose</h4>In adolescents (12-17 years), it is unknown whether COVID-19 vaccination reduces progression from COVID-19 to Long COVID (LC) beyond preventing SARS-CoV-2 infection. We assessed the effect of vaccination among SARS-CoV-2 infected adolescents.<h4>Methods and results</h4>Participants were recruited from over 60 US healthcare and community settings. The exposure was any COVID-19 vaccination 6 months prior to infection. The outcome was LC defined using the LC research index. Vaccinated (n = 724) and unvaccinated (n = 507) adolescents were matched on sex, infection date, and enrollment date. The risk of LC was 36 % lower (95 % CI, 17 %, 50 %) in vaccinated compared to unvaccinated participants.<h4>Conclusions</h4>Vaccination reduces the risk of LC. Given the profound impact LC c"],"journal":["Vaccine"],"pubmed_title":["Preventive effect of vaccination on long COVID in adolescents with SARS-CoV-2 infection."],"pmcid":["PMC12670331"],"funding_grant_id":["OT2 HL161847","OT2 HL156812","OT2 HL161841"],"pubmed_authors":["Thaweethai T","Carmilani M","Milner JD","Kleinman LC","Krishnamoorthy A","Stockwell MS","Mohandas S","Fitzgerald ML","Gross RS","Rhee KE","Tantisira K","Warburton D","RECOVER-Pediatrics Consortium","Reeder HT","Salisbury AL","Kinser PA","Pant DB","Jernigan TL","Wood JC","Snowden JN","Foulkes AS"],"additional_accession":[]},"is_claimable":false,"name":"Preventive effect of vaccination on long COVID in adolescents with SARS-CoV-2 infection.","description":"<h4>Purpose</h4>In adolescents (12-17 years), it is unknown whether COVID-19 vaccination reduces progression from COVID-19 to Long COVID (LC) beyond preventing SARS-CoV-2 infection. We assessed the effect of vaccination among SARS-CoV-2 infected adolescents.<h4>Methods and results</h4>Participants were recruited from over 60 US healthcare and community settings. The exposure was any COVID-19 vaccination 6 months prior to infection. The outcome was LC defined using the LC research index. Vaccinated (n = 724) and unvaccinated (n = 507) adolescents were matched on sex, infection date, and enrollment date. The risk of LC was 36 % lower (95 % CI, 17 %, 50 %) in vaccinated compared to unvaccinated participants.<h4>Conclusions</h4>Vaccination reduces the risk of LC. Given the profound impact LC c","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-05T20:44:32.996Z","creation":"2026-05-21T03:13:10.788Z"},"accession":"S-EPMC12670331","cross_references":{"pubmed":["41176968"],"doi":["10.1016/j.vaccine.2025.127907"]}}