{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Ge C"],"funding":["National Natural Science Foundation of China"],"pubmed_abstract":["Vaccination is considered one of the most effective methods for preventing avian influenza. The influenza neuraminidase (NA) enzyme is a promising candidate for a conserved influenza vaccine, offering long-term and effective cross-protection against the disease. The aim of this study is to develop a <i>Salmonella</i>-vectored vaccine with strong protective efficacy against H9N2 avian influenza virus. We utilized the antibiotic-free balanced-lethal system of regulated delayed-lysis <i>Salmonella</i> (χ11218) as the starting strain to construct a <i>focA</i> gene-deleted <i>Salmonella</i> (χYL57) strain. To optimize the vaccine design, we fused a tetravalent NA protein (tetramer-NA) with a chicken dendritic cell-targeting peptide (chDCpep) and delivered it via χ11218 or χYL57, yielding the c"],"journal":["Microbiology spectrum"],"pagination":["e0142125"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12671097"],"repository":["biostudies-literature"],"pubmed_title":["Protection against H9N2 challenge in chickens via &lt;i&gt;Salmonella&lt;/i&gt; with a &lt;i&gt;focA&lt;/i&gt; mutation delivered by a dendritic cell-targeted avian influenza virus NA protein tetramer."],"pmcid":["PMC12671097"],"funding_grant_id":["32072897"],"pubmed_authors":["Ge C","Zhang G","Wang C","Huang H","Jia F","Sun Y","Guo Q","Wang M","Jiang Y","Zhang T","He Y","Zhang Y","Tian Y","Gao Y","Wang W","Yang T","Gong J","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Protection against H9N2 challenge in chickens via &lt;i&gt;Salmonella&lt;/i&gt; with a &lt;i&gt;focA&lt;/i&gt; mutation delivered by a dendritic cell-targeted avian influenza virus NA protein tetramer.","description":"Vaccination is considered one of the most effective methods for preventing avian influenza. The influenza neuraminidase (NA) enzyme is a promising candidate for a conserved influenza vaccine, offering long-term and effective cross-protection against the disease. The aim of this study is to develop a <i>Salmonella</i>-vectored vaccine with strong protective efficacy against H9N2 avian influenza virus. We utilized the antibiotic-free balanced-lethal system of regulated delayed-lysis <i>Salmonella</i> (χ11218) as the starting strain to construct a <i>focA</i> gene-deleted <i>Salmonella</i> (χYL57) strain. To optimize the vaccine design, we fused a tetravalent NA protein (tetramer-NA) with a chicken dendritic cell-targeting peptide (chDCpep) and delivered it via χ11218 or χYL57, yielding the c","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-05T22:05:55.998Z","creation":"2026-05-22T03:15:41.99Z"},"accession":"S-EPMC12671097","cross_references":{"pubmed":["41143405"],"doi":["10.1128/spectrum.01421-25"]}}