biostudies-literatureUnknown9(12)Kumar S<h4>Background</h4>Capsule endoscopy (CE) is widely used for non-invasive evaluation of the small bowel; however, its effectiveness may be hindered by slow gastrointestinal transit and limited battery duration. A range of approaches-including pharmacologic agents, bowel-cleansing preparations, and magnetically guided control-has been introduced to improve the efficiency of the examination. This systematic review and meta-analysis compares the impact of these interventions on transit dynamics and examination completion.<h4>Methods</h4>Comprehensive searches of PubMed, Scopus, and Web of Science identified randomized controlled trials and observational studies assessing magnetic guidance, prokinetics, or purgatives in adults undergoing small-bowel capsule endoscopy. Outcomes of interest inclJGH open : an open access journal of gastroenterology and hepatologye70321https://www.ebi.ac.uk/biostudies/studies/S-EPMC12672391biostudies-literatureEffect of Multiple Pharmacological Interventions and Magnetic Control on Capsule Endoscopy Gastrointestinal Transit Time and Diagnostic Yield: A Systematic Review and Meta-Analysis.PMC12672391Ram SSyed SAlghzawi HMKhan MARKumar SParkash ASafdar RAli SSohaib ARiaz HIdrees TKumar AKumar BfalseEffect of Multiple Pharmacological Interventions and Magnetic Control on Capsule Endoscopy Gastrointestinal Transit Time and Diagnostic Yield: A Systematic Review and Meta-Analysis.<h4>Background</h4>Capsule endoscopy (CE) is widely used for non-invasive evaluation of the small bowel; however, its effectiveness may be hindered by slow gastrointestinal transit and limited battery duration. A range of approaches-including pharmacologic agents, bowel-cleansing preparations, and magnetically guided control-has been introduced to improve the efficiency of the examination. This systematic review and meta-analysis compares the impact of these interventions on transit dynamics and examination completion.<h4>Methods</h4>Comprehensive searches of PubMed, Scopus, and Web of Science identified randomized controlled trials and observational studies assessing magnetic guidance, prokinetics, or purgatives in adults undergoing small-bowel capsule endoscopy. Outcomes of interest incl2025-01-01T00:00:00Z2025 Dec2026-06-05T23:08:28.943Z2026-05-23T03:12:40.969ZS-EPMC126723914134634410.1002/jgh3.70321