biostudies-literatureUnknown203(12)Abdel-Badeea WIEMinia UniversityThe correlation between exposure to environmental pollutants and adverse impacts on fertility has been documented. Cadmium (Cd) is one of the most toxic elements that impairs female reproductive capacity. Syzygium cumini is a plant that contains polyphenols with strong antioxidant properties. Our study aimed to investigate the possible protective effects of Syzygium cumini fruit extract (SCFE) and quercetin (QU) against Cd-induced ovarian toxicity and apoptosis in rats assisted by measuring oxidative stress markers, hormonal profile, intrinsic apoptotic pathway, miRNA-204-5p, and histopathology. For that, 45 adult female rats were divided randomly into five groups; control, cadmium chloride (CdCl<sub>2</sub>), CdCl<sub>2</sub> + QU, CdCl<sub>2</sub> + SCFE200, and CdCl<sub>2</sub> + SCFE40Biological trace element research6172-6191https://www.ebi.ac.uk/biostudies/studies/S-EPMC12672602biostudies-literatureSyzygium cumini Fruit Extract and Quercetin Ameliorate Cadmium-Induced Ovarian Apoptosis in Rats Via miRNA- 204 - 5p-Mediated Bcl- 2 Upregulation and Bax/Caspase 9/Caspase 3 Downregulation.PMC12672602Abdel-Razik AHMahmoud AAAbdel-Wahab AAttia EZAbdel-Badeea WIEAbdelmohsen URHassanin KMAfalseSyzygium cumini Fruit Extract and Quercetin Ameliorate Cadmium-Induced Ovarian Apoptosis in Rats Via miRNA- 204 - 5p-Mediated Bcl- 2 Upregulation and Bax/Caspase 9/Caspase 3 Downregulation.The correlation between exposure to environmental pollutants and adverse impacts on fertility has been documented. Cadmium (Cd) is one of the most toxic elements that impairs female reproductive capacity. Syzygium cumini is a plant that contains polyphenols with strong antioxidant properties. Our study aimed to investigate the possible protective effects of Syzygium cumini fruit extract (SCFE) and quercetin (QU) against Cd-induced ovarian toxicity and apoptosis in rats assisted by measuring oxidative stress markers, hormonal profile, intrinsic apoptotic pathway, miRNA-204-5p, and histopathology. For that, 45 adult female rats were divided randomly into five groups; control, cadmium chloride (CdCl<sub>2</sub>), CdCl<sub>2</sub> + QU, CdCl<sub>2</sub> + SCFE200, and CdCl<sub>2</sub> + SCFE402025-01-01T00:00:00Z2025 Dec2026-06-05T22:21:21.079Z2026-05-22T03:16:22.378ZS-EPMC126726024036087810.1007/s12011-025-04632-y