{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu C"],"funding":["Beijing Xisike Clinical Oncology Research Foundation","National Natural Science Foundation of China","Peking University Third Hospital","National Clinical Key Specialty Construction Program, P. R. China"],"pagination":["5829-5840"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12672776"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["104(11)"],"pubmed_abstract":["Diffuse large B-cell lymphoma (DLBCL) is a highly aggressive form of non-Hodgkin lymphoma. B symptoms, including fever, night sweats and weight loss, are often overlooked but carry prognostic significance. The primary site of DLBCL also plays a crucial role in diagnosis and treatment decisions, and our study aims to explore the relationship among primary sites of DLBCL, the presence of B symptoms and patients' survival. 15,267 patients' data were analyzed in our study to investigate the potential relevance among B symptoms, primary sites and patients' survival. We assessed the influence of primary site and B symptoms on survival with the use of Survival package and Kaplan-Meier survival analysis. Age, race and Ann-Arbor stage were significantly associated with the presence of B symptoms. T"],"journal":["Annals of hematology"],"pubmed_title":["A comprehensive analysis of B symptoms reveals prognosis and heterogeneity across different sites of diffuse large B-cell lymphoma."],"pmcid":["PMC12672776"],"funding_grant_id":["BYSYZD2019026","81800195","Y-NCJH202201-0049"],"pubmed_authors":["Wu C","Qi W","Hao X","Chen C","Wang J","Yang F","Li M","Liu X","Zhang W","Liu Y","Zhu M","Zhang Y","Xiao J","Yang P","Wu S","Bao F","Yan C","Yuan X","Yu Z"],"additional_accession":[]},"is_claimable":false,"name":"A comprehensive analysis of B symptoms reveals prognosis and heterogeneity across different sites of diffuse large B-cell lymphoma.","description":"Diffuse large B-cell lymphoma (DLBCL) is a highly aggressive form of non-Hodgkin lymphoma. B symptoms, including fever, night sweats and weight loss, are often overlooked but carry prognostic significance. The primary site of DLBCL also plays a crucial role in diagnosis and treatment decisions, and our study aims to explore the relationship among primary sites of DLBCL, the presence of B symptoms and patients' survival. 15,267 patients' data were analyzed in our study to investigate the potential relevance among B symptoms, primary sites and patients' survival. We assessed the influence of primary site and B symptoms on survival with the use of Survival package and Kaplan-Meier survival analysis. Age, race and Ann-Arbor stage were significantly associated with the presence of B symptoms. T","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T22:15:06.283Z","creation":"2026-05-22T03:15:44.946Z"},"accession":"S-EPMC12672776","cross_references":{"pubmed":["41071290"],"doi":["10.1007/s00277-025-06579-5"]}}