biostudies-literatureWu CBeijing Xisike Clinical Oncology Research FoundationNational Natural Science Foundation of ChinaPeking University Third HospitalNational Clinical Key Specialty Construction Program, P. R. China5829-5840https://www.ebi.ac.uk/biostudies/studies/S-EPMC12672776biostudies-literatureUnknown104(11)Diffuse large B-cell lymphoma (DLBCL) is a highly aggressive form of non-Hodgkin lymphoma. B symptoms, including fever, night sweats and weight loss, are often overlooked but carry prognostic significance. The primary site of DLBCL also plays a crucial role in diagnosis and treatment decisions, and our study aims to explore the relationship among primary sites of DLBCL, the presence of B symptoms and patients' survival. 15,267 patients' data were analyzed in our study to investigate the potential relevance among B symptoms, primary sites and patients' survival. We assessed the influence of primary site and B symptoms on survival with the use of Survival package and Kaplan-Meier survival analysis. Age, race and Ann-Arbor stage were significantly associated with the presence of B symptoms. TAnnals of hematologyA comprehensive analysis of B symptoms reveals prognosis and heterogeneity across different sites of diffuse large B-cell lymphoma.PMC12672776BYSYZD201902681800195Y-NCJH202201-0049Wu CQi WHao XChen CWang JYang FLi MLiu XZhang WLiu YZhu MZhang YXiao JYang PWu SBao FYan CYuan XYu ZfalseA comprehensive analysis of B symptoms reveals prognosis and heterogeneity across different sites of diffuse large B-cell lymphoma.Diffuse large B-cell lymphoma (DLBCL) is a highly aggressive form of non-Hodgkin lymphoma. B symptoms, including fever, night sweats and weight loss, are often overlooked but carry prognostic significance. The primary site of DLBCL also plays a crucial role in diagnosis and treatment decisions, and our study aims to explore the relationship among primary sites of DLBCL, the presence of B symptoms and patients' survival. 15,267 patients' data were analyzed in our study to investigate the potential relevance among B symptoms, primary sites and patients' survival. We assessed the influence of primary site and B symptoms on survival with the use of Survival package and Kaplan-Meier survival analysis. Age, race and Ann-Arbor stage were significantly associated with the presence of B symptoms. T2025-01-01T00:00:00Z2025 Nov2026-06-05T22:15:06.283Z2026-05-22T03:15:44.946ZS-EPMC126727764107129010.1007/s00277-025-06579-5