{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(6)"],"submitter":["Bongert M"],"pubmed_abstract":["Multiple sclerosis is a chronic inflammatory disease affecting the central nervous system. While treatment made huge advances, progression remains a challenge. Eomesodermin<sup>+</sup> Th cells are associated with cytotoxicity, neuroinflammation and disease progression in secondary progressive multiple sclerosis. We performed a prospective longitudinal study over one year to investigate the role of Eomesodermin<sup>+</sup> T cells in multiple sclerosis progression and neurodegeneration. Patients underwent detailed clinical assessment and immunophenotyping. In a subcohort of patients, cross-sectional magnetic resonance imaging using voxel-based morphometry was performed. Frequencies of Eomesodermin<sup>+</sup> Th cells could differentiate between patients with secondary and primary progress"],"journal":["Brain communications"],"pagination":["fcaf415"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12673330"],"repository":["biostudies-literature"],"pubmed_title":["Eomesodermin-expressing CD4 Th cells and association with multiple sclerosis progression and brain atrophy."],"pmcid":["PMC12673330"],"pubmed_authors":["Bratek D","Beyer L","Gerwert K","Ayzenberg I","Gold R","Vohl K","Lukas C","Mattukat A","Faissner S","Schneider R","Ceylan U","Schmitz I","Ladopoulos T","Schonauer E","Bongert M","Trendelenburg P","Yamamura T"],"additional_accession":[]},"is_claimable":false,"name":"Eomesodermin-expressing CD4 Th cells and association with multiple sclerosis progression and brain atrophy.","description":"Multiple sclerosis is a chronic inflammatory disease affecting the central nervous system. While treatment made huge advances, progression remains a challenge. Eomesodermin<sup>+</sup> Th cells are associated with cytotoxicity, neuroinflammation and disease progression in secondary progressive multiple sclerosis. We performed a prospective longitudinal study over one year to investigate the role of Eomesodermin<sup>+</sup> T cells in multiple sclerosis progression and neurodegeneration. Patients underwent detailed clinical assessment and immunophenotyping. In a subcohort of patients, cross-sectional magnetic resonance imaging using voxel-based morphometry was performed. Frequencies of Eomesodermin<sup>+</sup> Th cells could differentiate between patients with secondary and primary progress","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-23T03:25:50.937Z","creation":"2026-05-23T03:13:49.423Z"},"accession":"S-EPMC12673330","cross_references":{"pubmed":["41346466"],"doi":["10.1093/braincomms/fcaf415"]}}