biostudies-literatureNi JShanghai Action Plan for Science, Technology and InnovationShanghai Oriental Talent Program (Outstanding Project)Noncommunicable Chronic Diseases-National Science and Technology Major ProjectShanghai Leading Talent Program of Eastern Talent PlanThree-year Action Program of Shanghai Municipality for Strengthening the Construction of the Public Health System434-442https://www.ebi.ac.uk/biostudies/studies/S-EPMC12673452biostudies-literatureUnknown28(1)<h4>Aims</h4>Serum 1,5-anhydroglucitol (1,5-AG) indicates glycemic control over 1-2 weeks and is particularly useful for monitoring postprandial hyperglycemia. However, its predictive value for long-term outcomes in type 2 diabetes has not been fully established. Therefore, our study intends to examine the correlation between 1,5-AG and risk of all-cause and cardiovascular mortality.<h4>Methods</h4>In this real-world cohort study, 3721 patients with type 2 diabetes were classified by 1,5-AG levels (<6.0 and ≥6.0 μg/mL). Cox proportional hazards regression models served to analyse the link between 1,5-AG levels and risk of all-cause and cardiovascular mortality, while restricted cubic splines were employed to investigate linearity of this association.<h4>Results</h4>Across a median 7.4-yearDiabetes, obesity & metabolismLow serum 1,5-anhydroglucitol is associated with increased risk of all-cause and cardiovascular mortality in type 2 diabetes: A real-world cohort study.PMC12673452GWVI-11.2-YQ07LJ2024121GWVI-11.1-4923JS14010002024ZD05320012024ZD0532000Ni JLu WWang CChen LLu JCai JWang YSu HXia TZhou JfalseLow serum 1,5-anhydroglucitol is associated with increased risk of all-cause and cardiovascular mortality in type 2 diabetes: A real-world cohort study.<h4>Aims</h4>Serum 1,5-anhydroglucitol (1,5-AG) indicates glycemic control over 1-2 weeks and is particularly useful for monitoring postprandial hyperglycemia. However, its predictive value for long-term outcomes in type 2 diabetes has not been fully established. Therefore, our study intends to examine the correlation between 1,5-AG and risk of all-cause and cardiovascular mortality.<h4>Methods</h4>In this real-world cohort study, 3721 patients with type 2 diabetes were classified by 1,5-AG levels (<6.0 and ≥6.0 μg/mL). Cox proportional hazards regression models served to analyse the link between 1,5-AG levels and risk of all-cause and cardiovascular mortality, while restricted cubic splines were employed to investigate linearity of this association.<h4>Results</h4>Across a median 7.4-year2026-01-01T00:00:00Z2026 Jan2026-06-07T04:43:44.071Z2026-06-07T03:07:08.972ZS-EPMC126734524109040710.1111/dom.70214