biostudies-literatureWu JNational High Level Hospital Clinical Research FundingNational Natural Science Foundation of China856https://www.ebi.ac.uk/biostudies/studies/S-EPMC12673777biostudies-literatureUnknown25(1)<h4>Objective</h4>This study aimed to compare and rank antihypertensive agents based on their urate-lowering effects in patients with hypertension and hyperuricemia.<h4>Methods</h4>We systematically searched PubMed, Embase, the Cochrane Library, the Chinese National Knowledge Infrastructure, and the Wanfang databases for eligible trials published up to September 2023. Randomized controlled trials that directly compared different antihypertensive agents in hypertensive patients with hyperuricemia were included. Pairwise and network meta-analyses were conducted using odds ratios and weighted mean differences with 95% confidence intervals. The surface under the cumulative ranking area (SUCRA) was used to rank the efficacy of the antihypertensive treatments.<h4>Results</h4>A total of 172 trialBMC cardiovascular disordersAntihypertensive drugs for hyperuricemia in patients with hypertension: a systematic review and network meta-analysis of Chinese trials.PMC126737772022-PUMCH-B-04482071841Wu JZhang YZeng XDi HfalseAntihypertensive drugs for hyperuricemia in patients with hypertension: a systematic review and network meta-analysis of Chinese trials.<h4>Objective</h4>This study aimed to compare and rank antihypertensive agents based on their urate-lowering effects in patients with hypertension and hyperuricemia.<h4>Methods</h4>We systematically searched PubMed, Embase, the Cochrane Library, the Chinese National Knowledge Infrastructure, and the Wanfang databases for eligible trials published up to September 2023. Randomized controlled trials that directly compared different antihypertensive agents in hypertensive patients with hyperuricemia were included. Pairwise and network meta-analyses were conducted using odds ratios and weighted mean differences with 95% confidence intervals. The surface under the cumulative ranking area (SUCRA) was used to rank the efficacy of the antihypertensive treatments.<h4>Results</h4>A total of 172 trial2025-01-01T00:00:00Z2025 Dec2026-06-07T04:40:50.52Z2026-06-07T03:06:21.424ZS-EPMC126737774133142410.1186/s12872-025-05339-7