{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kabil MF"],"funding":["National Science Foundation under the Established Program to Stimulate Competitive Research (EPSCoR)","National Science Foundation"],"pagination":["e09099"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12674095"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(48)"],"pubmed_abstract":["Superparamagnetic iron oxide nanoparticle (SPION) clusters produce localized magnetic field inhomogeneities that enhance negative contrast in magnetic resonance imaging (MRI). It is shown that high transverse relaxivity (r<sub>2</sub>) can be obtained by clustering hydrophobic SPIONs with an average core diameter of ≈7 nm via self-assembly with amphiphilic polyethylene glycol-b-poly(L-Leucine) block copolymers, PEG<sub>n</sub>-b-p(L-Leu)<sub>m</sub>, where the PEG chains are terminated by methoxy (CH<sub>3</sub>O-PEG<sub>n</sub>) or hydroxyl groups (HO-PEG<sub>n</sub>). Clusters ranging from 65 to 85 nm in diameter are formed by polymer coating and stabilization of hydrophobic SPION aggregates and yield high r<sub>2</sub> values ranging from 226 to 342 s<sup>-1</sup> mm Fe<sup>-1</sup> wit"],"journal":["Small (Weinheim an der Bergstrasse, Germany)"],"pubmed_title":["Multicore SPION Clustering within Poly(amino acid) Corrals for Enhanced MRI Contrast and Drug Release."],"pmcid":["PMC12674095"],"funding_grant_id":["1655221","2305402"],"pubmed_authors":["Kabil MF","Bothun GD","Mills R","Scholz C","Walsh EG","Akinmola AT","Pan A","Anik MI"],"additional_accession":[]},"is_claimable":false,"name":"Multicore SPION Clustering within Poly(amino acid) Corrals for Enhanced MRI Contrast and Drug Release.","description":"Superparamagnetic iron oxide nanoparticle (SPION) clusters produce localized magnetic field inhomogeneities that enhance negative contrast in magnetic resonance imaging (MRI). It is shown that high transverse relaxivity (r<sub>2</sub>) can be obtained by clustering hydrophobic SPIONs with an average core diameter of ≈7 nm via self-assembly with amphiphilic polyethylene glycol-b-poly(L-Leucine) block copolymers, PEG<sub>n</sub>-b-p(L-Leu)<sub>m</sub>, where the PEG chains are terminated by methoxy (CH<sub>3</sub>O-PEG<sub>n</sub>) or hydroxyl groups (HO-PEG<sub>n</sub>). Clusters ranging from 65 to 85 nm in diameter are formed by polymer coating and stabilization of hydrophobic SPION aggregates and yield high r<sub>2</sub> values ranging from 226 to 342 s<sup>-1</sup> mm Fe<sup>-1</sup> wit","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-07T04:43:58.44Z","creation":"2026-06-07T03:07:11.331Z"},"accession":"S-EPMC12674095","cross_references":{"pubmed":["41110154"],"doi":["10.1002/smll.202509099"]}}