{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["35(1)"],"submitter":["Meng J"],"pubmed_abstract":["In goats, most follicles in the ovaries will be atresia and only a few dominant follicles (DFs) may eventually mature and ovulate at a follicular wave. To investigate the potential microRNAs (miRNAs) that regulate the expression of genes associated with follicular dominance or atresia, small RNA sequencing was performed on granulosa cells of DF and subordinate follicle at the first follicular wave in goats. A total of 108 differentially expressed miRNAs were detected in the two types of follicle granulosa cells: 16 upregulated miRNAs and 92 downregulated miRNAs. Kyoto Encyclopedia of Genes and Genomes analysis of the target genes showed that <i>TKTL1</i>, <i>LOC102187810</i>, <i>LOC102184409</i> and <i>ALDOA</i> are closely associated with follicle dominance and are involved in the pentose"],"journal":["Animal biotechnology"],"pagination":["2259967"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12674301"],"repository":["biostudies-literature"],"pubmed_title":["Deciphering the miRNA transcriptome of granulosa cells from dominant and subordinate follicles at first follicular wave in goat."],"pmcid":["PMC12674301"],"pubmed_authors":["An Q","Wu Z","Meng J","Song X","Zhao Y"],"additional_accession":[]},"is_claimable":false,"name":"Deciphering the miRNA transcriptome of granulosa cells from dominant and subordinate follicles at first follicular wave in goat.","description":"In goats, most follicles in the ovaries will be atresia and only a few dominant follicles (DFs) may eventually mature and ovulate at a follicular wave. To investigate the potential microRNAs (miRNAs) that regulate the expression of genes associated with follicular dominance or atresia, small RNA sequencing was performed on granulosa cells of DF and subordinate follicle at the first follicular wave in goats. A total of 108 differentially expressed miRNAs were detected in the two types of follicle granulosa cells: 16 upregulated miRNAs and 92 downregulated miRNAs. Kyoto Encyclopedia of Genes and Genomes analysis of the target genes showed that <i>TKTL1</i>, <i>LOC102187810</i>, <i>LOC102184409</i> and <i>ALDOA</i> are closely associated with follicle dominance and are involved in the pentose","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-07T04:48:10.507Z","creation":"2026-06-07T03:06:10.181Z"},"accession":"S-EPMC12674301","cross_references":{"pubmed":["37750325"],"doi":["10.1080/10495398.2023.2259967"]}}